INT150744

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.35
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (SYP)
Anatomy Link Frequency
dendrites 2
neuron 2
ganglion cells 2
SYP (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 7 74.52 Quite High
headache 2 73.32 Quite High
endometriosis 4 50.00 Quite Low
Glutamate 3 28.52 Quite Low
glial activation 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 98.92 Very High Very High Very High
Cancer 4 97.76 Very High Very High Very High
Infection 17 96.76 Very High Very High Very High
Necrosis 1 95.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 22 89.00 High High
Medulloblastoma 5 88.72 High High
Rhinitis 1 86.00 High High
Calcification 1 80.52 Quite High
Diplopia 2 75.00 Quite High
Vomiting 2 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry revealed expression of synaptophysin by many of the dysplastic ganglion cells, with some co-expressing neurofilament protein and occasionally glial fibrillary acidic protein (GFAP).
Negative_regulation (revealed) of Gene_expression (expression) of synaptophysin in ganglion cells associated with ganglion cysts
1) Confidence 0.41 Published 2008 Journal Brain Pathol. Section Abstract Doc Link 18363942 Disease Relevance 1.13 Pain Relevance 0.11
Immunohistochemical staining revealed diffuse expression of synaptophysin and neurofilament protein, and focal expression of glial fibrillary acidic protein, S-100 protein, desmin, and myoglobin.
Negative_regulation (revealed) of Gene_expression (expression) of synaptophysin
2) Confidence 0.41 Published 2008 Journal Brain Tumor Pathol Section Abstract Doc Link 18415665 Disease Relevance 0.71 Pain Relevance 0.09
Biopsy samples from eutopic endometrium were used for immunohistochemical staining to detect synaptophysin (SYN) and neuron-specific enolase (NSE) expression in women with and without endometriosis.
Negative_regulation (detect) of Gene_expression (expression) of synaptophysin in neuron
3) Confidence 0.41 Published 2010 Journal Hum. Reprod. Section Body Doc Link 19910323 Disease Relevance 0 Pain Relevance 0
Decreases in the expression of synaptophysin (SYN), an integral protein in presynaptic terminals, and microtubule-associated protein 2 (MAP2), a marker for neuronal cell bodies and dendrites, reflect neurodegeneration severity and have been found to correlate to the degree of neurocognitive impairment in persons with HIV [26].
Negative_regulation (Decreases) of Gene_expression (expression) of synaptophysin in dendrites associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.50 Pain Relevance 0

General Comments

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