INT150787

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 1.02
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (ZNF398, SPARC) nucleus (ZNF398, SPARC) DNA binding (ZNF398)
cytoplasm (SPARC) extracellular space (SPARC) signal transduction (SPARC)
Anatomy Link Frequency
lung 4
ZNF398 (Homo sapiens)
SPARC (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 99.98 Very High Very High Very High
metalloproteinase 2 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.88 Very High Very High Very High
Lung Cancer 4 99.60 Very High Very High Very High
Metastasis 4 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we demonstrated that upregulation of SPARC expression by NS398 in human lung cancer cells is mediated by promoter demethylation and associated with a decrease in DNA methyltransferase (DNMT) expression.
NS398 Positive_regulation (upregulation) of Gene_expression (expression) of SPARC in lung associated with lung cancer
1) Confidence 0.13 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18367635 Disease Relevance 0.49 Pain Relevance 0.50
The nonsteroidal anti-inflammatory drug NS398 reactivates SPARC expression via promoter demethylation to attenuate invasiveness of lung cancer cells.
NS398 Positive_regulation (reactivates) of Gene_expression (expression) of SPARC in lung associated with lung cancer, inflammation and cinod
2) Confidence 0.09 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 18367635 Disease Relevance 0.53 Pain Relevance 0.55

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox