INT150805

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.88
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBS1) extracellular region (THBS1) cell adhesion (THBS1)
structural molecule activity (THBS1)
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 12 97.56 Very High Very High Very High
cINOD 12 95.48 Very High Very High Very High
Pain 4 95.32 Very High Very High Very High
tolerance 1 73.44 Quite High
cytokine 6 10.36 Low Low
imagery 7 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 245 99.10 Very High Very High Very High
Pressure And Volume Under Development 7 95.74 Very High Very High Very High
Vomiting 5 95.48 Very High Very High Very High
Pain 4 95.32 Very High Very High Very High
Metastasis 21 93.80 High High
Glioblastoma 1 90.04 High High
Apoptosis 23 89.84 High High
Melanoma 17 87.64 High High
Malignant Neoplastic Disease 5 86.68 High High
Lung Cancer 5 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that several negative regulators of cell invasion, including secreted protein acidic and rich in cysteine (SPARC), thrombospondin 1 (TSP-1), thrombospondin 3 (TSP-3), and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) are upregulated by NS398.
Localization (secreted) of thrombospondin 1 associated with metalloproteinase
1) Confidence 0.46 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18367635 Disease Relevance 0.50 Pain Relevance 0.52
We found that several negative regulators of cell invasion, including secreted protein acidic and rich in cysteine (SPARC), thrombospondin 1 (TSP-1), thrombospondin 3 (TSP-3), and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) are upregulated by NS398.
Localization (secreted) of TSP-1 associated with metalloproteinase
2) Confidence 0.46 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18367635 Disease Relevance 0.50 Pain Relevance 0.52
First, there is loss of both alleles of wild-type p53, which causes a 20-fold drop in secreted TSP and a fourfold increase in secreted VEGF [7].
Localization (secreted) of TSP
3) Confidence 0.07 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.05 Pain Relevance 0.05
The 5 symptomatic patients in this study experienced a rapid subjective palliation of pain, nausea, and ascites [18].Metronomic administration of chemotherapy, defined as the frequent administration of doses substantially lower than the maximum tolerated dose, can suppress tumor growth, probably through stimulation of the release of thrombospondin 1, a potent and endothelial-specific inhibitor of angiogenesis [19].
Localization (release) of thrombospondin 1 associated with pain, pressure and volume under development, cancer and vomiting
4) Confidence 0.03 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.83 Pain Relevance 0.13

General Comments

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