INT150806

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.64
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SPARC) extracellular space (SPARC) extracellular region (SPARC)
proteinaceous extracellular matrix (SPARC) nucleus (SPARC) intracellular (SPARC)
Anatomy Link Frequency
PSC 1
SPARC (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1 96.52 Very High Very High Very High
cINOD 8 95.48 Very High Very High Very High
dexamethasone 16 55.28 Quite High
Pain 15 5.00 Very Low Very Low Very Low
palliative 9 5.00 Very Low Very Low Very Low
celiac plexus 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
transdermal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 2 99.72 Very High Very High Very High
Pancreatic Cancer 64 99.00 Very High Very High Very High
Apoptosis 32 97.44 Very High Very High Very High
Cancer 109 95.44 Very High Very High Very High
Prostate Cancer 26 94.08 High High
Metastasis 13 93.80 High High
Malignant Neoplastic Disease 5 93.64 High High
Adenocarcinoma 3 90.28 High High
Disease 53 87.20 High High
Colon Cancer 4 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that several negative regulators of cell invasion, including secreted protein acidic and rich in cysteine (SPARC), thrombospondin 1 (TSP-1), thrombospondin 3 (TSP-3), and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) are upregulated by NS398.
Localization (secreted) of SPARC associated with metalloproteinase
1) Confidence 0.53 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18367635 Disease Relevance 0.50 Pain Relevance 0.47
The level of paracrine secreted protein acidic and rich in cysteine (SPARC) from PSC has been demonstrated to be inversely proportional to survival.101 This makes SPARC in the PSCs an attractive adjunct target.
Localization (secreted) of SPARC in PSC associated with primary sclerosing cholangitis
2) Confidence 0.30 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 1.09 Pain Relevance 0
Secreted protein acidic and rich in cysteine (SPARC; osteonectin, BM-40), a family member of matricellular proteins including thrombospondins, tenascin, and osteopontin, may serve as a tumor suppressor 64.
Localization (Secreted) of osteonectin associated with cancer
3) Confidence 0.16 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.53 Pain Relevance 0.03
Secreted protein acidic and rich in cysteine (SPARC; osteonectin, BM-40), a family member of matricellular proteins including thrombospondins, tenascin, and osteopontin, may serve as a tumor suppressor 64.
Localization (Secreted) of BM-40 associated with cancer
4) Confidence 0.16 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

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