INT150809

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.60
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
Anatomy Link Frequency
plasma 1
blood 1
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 159 100.00 Very High Very High Very High
rheumatoid arthritis 252 98.84 Very High Very High Very High
cINOD 10 95.48 Very High Very High Very High
Arthritis 20 84.08 Quite High
cytokine 8 74.44 Quite High
Inflammation 22 74.08 Quite High
Osteoarthritis 4 45.72 Quite Low
imagery 1 12.12 Low Low
Leflunomide 4 9.52 Low Low
methotrexate 20 6.36 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 252 98.84 Very High Very High Very High
Metastasis 18 93.80 High High
Lung Cancer 2 90.96 High High
Arthropathy 28 87.64 High High
Experimental Arthritis 4 84.08 Quite High
INFLAMMATION 28 81.96 Quite High
Cancer 56 72.72 Quite High
Disease 32 71.52 Quite High
Lymphatic System Cancer 4 65.32 Quite High
Benign Prostatic Hypertrophy 115 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Individual preparations of TIMP-1, TIMP-2, TIMP-3, and TIMP-4 were reconstituted in PBS to 0.5 ?
Localization (preparations) of TIMP-2
1) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.12 Pain Relevance 0
In addition, immunoglobulin G (IgG) from blood samples of RA patients possessing TIMP antibodies was isolated on protein A–sepharose and tested for the in vitro ability to neutralize TIMP-2-dependent effects on metalloproteinase 9 (MMP9).
Localization (neutralize) of TIMP-2 in blood associated with metalloproteinase and rheumatoid arthritis
2) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257425 Disease Relevance 0.73 Pain Relevance 0.48
In the established experimental system, the neutralization of TIMP-2 with purified IgG interfered with TIMP-2 binding to the catalytic domain of MMP9.
Localization (neutralization) of TIMP-2
3) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.64 Pain Relevance 0.27
Neutralization of TIMP-2 activity by antibodies from RA patients
Localization (Neutralization) of TIMP-2 associated with rheumatoid arthritis
4) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.26 Pain Relevance 0.10
Antibodies used were a mouse monoclonal against TIMP2 (1?
Localization (monoclonal) of TIMP2
5) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.24 Pain Relevance 0
We found that several negative regulators of cell invasion, including secreted protein acidic and rich in cysteine (SPARC), thrombospondin 1 (TSP-1), thrombospondin 3 (TSP-3), and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) are upregulated by NS398.
Localization (secreted) of TIMP-2 associated with metalloproteinase
6) Confidence 0.44 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18367635 Disease Relevance 0.51 Pain Relevance 0.53
RPN 2610, RPN 2617, RPN 2613, RPN 2614, RPN 2611, RPN 2618, RPN 2612) for the determination of MMP1, MMP2, MMP3, MMP9, TIMP1, TIMP2, and MTC1 concentrations in the blood plasma of the patients and the control group.
Localization (concentrations) of TIMP2 in plasma
7) Confidence 0.28 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.11 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox