INT150825

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 6.65
Pain Relevance 6.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Anatomy Link Frequency
brain 3
cortex 2
nucleus accumbens 1
Comt (Mus musculus)
Comt - V158M (1)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 277 100.00 Very High Very High Very High
Morphine 58 99.36 Very High Very High Very High
Codeine 1 99.16 Very High Very High Very High
Opioid 9 98.40 Very High Very High Very High
analgesia 7 98.32 Very High Very High Very High
Nucleus accumbens 54 98.10 Very High Very High Very High
Hippocampus 59 97.08 Very High Very High Very High
Pain 118 96.00 Very High Very High Very High
imagery 14 95.50 Very High Very High Very High
Dopamine 182 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 43 99.76 Very High Very High Very High
Toxicity 1 99.76 Very High Very High Very High
Disease 49 99.60 Very High Very High Very High
Schizophrenia 139 98.92 Very High Very High Very High
Eating Disorder 6 98.32 Very High Very High Very High
Manic Depressive Disorder 18 97.76 Very High Very High Very High
Cognitive Disorder 67 96.96 Very High Very High Very High
Drug Dependence 9 96.36 Very High Very High Very High
Pain 146 96.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 54 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rodent brain a single transcript codes for both soluble (S-) and membrane bound (MB-) COMT through a leaky scanning mechanism [18].
COMT Binding (bound) of in brain associated with catechol-o-methyltransferase
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.47 Pain Relevance 0.17
While these results might suggest that there is an important molecular interaction between Comt and drugs of abuse, it is important to note that these studies were carried out with less specific, first generation COMT inhibitors.
Comt Binding (interaction) of associated with catechol-o-methyltransferase
2) Confidence 0.40 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.08 Pain Relevance 0.81
Top probe sets were selected based on probe set specificity, strength of association to the Comt locus, biological function, and expression pattern for each relevant brain region in the AIBS (www.brain-map.org).


Comt Binding (association) of in brain
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0 Pain Relevance 0.09
Several studies on obsessive compulsive disorder have found associations with COMT [57-60].
COMT Binding (associations) of associated with catechol-o-methyltransferase and anxiety disorder
4) Confidence 0.35 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.43 Pain Relevance 0.65
Since functional imaging studies show that dorsolateral prefrontal cortex (DLPFC) is activated during the flanker task, and since anatomical studies [24] show that the structure of DLPFC is highly heritable, we might have expected to see a stronger association with COMT.
COMT Spec (might) Binding (association) of in cortex associated with catechol-o-methyltransferase and imagery
5) Confidence 0.35 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.28 Pain Relevance 0.32
Although, collectively, the human genetic and animal model studies designed to identify schizophrenia susceptibility genes from the 22q11.2 region have implicated primarily three genes: proline dehydrogenase (PRODH), ZDHHC8 and catechol-O-methyltransferase (COMT) [21]–[25] and their interactions [26], [27], a study by Liu et al. [22] presented suggestive evidence that common variants located at the 3?
COMT Binding (interactions) of associated with catechol-o-methyltransferase and schizophrenia
6) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.79 Pain Relevance 0.13
Although, collectively, the human genetic and animal model studies designed to identify schizophrenia susceptibility genes from the 22q11.2 region have implicated primarily three genes: proline dehydrogenase (PRODH), ZDHHC8 and catechol-O-methyltransferase (COMT) [21]–[25] and their interactions [26], [27], a study by Liu et al. [22] presented suggestive evidence that common variants located at the 3?
catechol-O-methyltransferase Binding (interactions) of associated with catechol-o-methyltransferase and schizophrenia
7) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.85 Pain Relevance 0.13
Polymorphisms in COMT are often associated with CNS diseases such as schizophrenia, anorexia nervosa, bipolar disorder, anxiety, and substance use disorders [24].
COMT Binding (associated) of associated with drug dependence, catechol-o-methyltransferase, manic depressive disorder, anxiety disorder, disease, eating disorder and schizophrenia
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.75 Pain Relevance 0.33
Out of 24, 60, 18, and 30 probe sets mapping to the Comt locus in the hippocampus, striatum, prefrontal cortex and nucleus accumbens, respectively, we used our filtering criteria to select the 10 strongest traits controlled by variation in Comt from each region.
Comt Binding (variation) of in cortex associated with nucleus accumbens and hippocampus
9) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0 Pain Relevance 0.10
A more efficient first initiation site in human COMT mRNA leads to the production of more membrane bound MB-COMT than soluble S-COMT in human brain [30] which, despite having a lower enzyme capacity, has a higher affinity for dopamine and other neurotransmitters [31], [32], [33].
MB-COMT Binding (bound) of in brain associated with catechol-o-methyltransferase, neurotransmitter and dopamine
10) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.59 Pain Relevance 0.38
A recent finding showed that COMT genotype was related to performance on the Wisconsin Card Sorting Test of executive cognition [55].
COMT Binding (genotype) of associated with catechol-o-methyltransferase and cognitive disorder
11) Confidence 0.30 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.55 Pain Relevance 0.56
COMT activity alterations associated with Val158Met impacts on responsiveness of the µ-opioid system, which is activated in response to pain and stressors, and typically reduces pain and response to stress [13], [14].
COMT Binding (associated) of associated with stress, pain and opioid
12) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.62 Pain Relevance 0.84
Out of 24, 60, 18, and 30 probe sets mapping to the Comt locus in the hippocampus, striatum, prefrontal cortex and nucleus accumbens, respectively, we used our filtering criteria to select the 10 strongest traits controlled by variation in Comt from each region.
Comt Binding (variation) of in nucleus accumbens associated with nucleus accumbens and hippocampus
13) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0 Pain Relevance 0.10
The COMT V158M variant has been associated with decreased morphine requirements for analgesia.
COMT V158M variant (V158M) Binding (associated) of associated with analgesia and morphine
14) Confidence 0.04 Published 2008 Journal Pharmacogenomics Section Abstract Doc Link 18370847 Disease Relevance 1.26 Pain Relevance 1.82

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox