INT150826

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.65
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pkd1) plasma membrane (Pkd1) nucleus (Pkd1)
cilium (Pkd1)
Anatomy Link Frequency
cilium 1
ciliary 1
gland 1
Pkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 5 99.92 Very High Very High Very High
Mechanotransduction 2 97.12 Very High Very High Very High
TRP channel 9 72.92 Quite High
Mechanosensation 10 71.72 Quite High
fibrosis 6 60.72 Quite High
Bioavailability 4 50.40 Quite High
palliative 3 50.00 Quite Low
imagery 35 22.88 Low Low
Somatostatin 8 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Respiratory Disease 16 99.74 Very High Very High Very High
Polycystic Kidney Disease 143 99.14 Very High Very High Very High
Toxicity 14 99.00 Very High Very High Very High
Repression 24 98.56 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 114 97.92 Very High Very High Very High
Cancer 6 95.12 Very High Very High Very High
Cyst 92 94.72 High High
Death 5 91.88 High High
Hypothermia 4 91.76 High High
Stress 23 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When cells were grown in minimal medium with increasing concentrations of PC1 and PC2, beta-galactosidase activity was clearly repressed in a dose-dependent manner suggesting a modulation of the guanine riboswitch gene regulation by both molecules.
Positive_regulation (increasing) of PC1
1) Confidence 0.37 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0 Pain Relevance 0
PC1-dependent bacterial growth inhibition requires guaA to be riboswitch-regulated
Positive_regulation (requires) of PC1
2) Confidence 0.35 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.10 Pain Relevance 0
Consistent with these results, we found that the potency of PC1 was significantly increased by preventing its oxidation using a reductive agent such as DTT in susceptibility tests in vitro (Figure S5).


Positive_regulation (increased) of PC1 associated with potency
3) Confidence 0.33 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.18 Pain Relevance 0.08
The selective antibacterial activity of PC1 toward S. aureus was also supported by the lack of apparent toxicity for mice treated with the experimental compound at concentrations as high as 100 µg/gland with no sign of discomfort including vocalizations, curved back, piloerection and hypothermia.
Positive_regulation (supported) of PC1 in gland associated with hypothermia, toxicity and bacterial respiratory disease
4) Confidence 0.33 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.48 Pain Relevance 0
More specifically, ciliary polycystin-1 and polycystin-2 function together with ryanodine receptors to mediate mechanotransduction into the intracellular Ca2+ signaling response (Fig. 3).
Positive_regulation (ciliary) of polycystin-1 in ciliary associated with mechanotransduction
5) Confidence 0.30 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.05 Pain Relevance 0.08
Mutations of PKD1 gene, encoding the polycystin-1 protein, result in ADPKD type I (ADPKD1) which is responsible for approximately 85% of ADPKD cases.
Positive_regulation (Mutations) of PKD1 associated with autosomal dominant polycystic kidney
6) Confidence 0.29 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.69 Pain Relevance 0.06
Activation of mTOR was also found in animal models of recessive PKD such as the bpk and orpk-rescue, suggesting that mutations in polycystin-1 are not critical form mTOR activation.
Positive_regulation (activation) of polycystin-1
7) Confidence 0.28 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.51 Pain Relevance 0
Although both channels localize to the cilium of tubular epithelial cells and are required for flow-induced Ca2+ signals, the lack of renal cysts in TRPV4-deficient animals indicates that activation of the ciliary polycystin-1–TRPP2 complex by a mechanism other than flow-induced deflection of the cilium might be critical for the regulation of tubular morphology.


Positive_regulation (activation) of polycystin-1 in cilium associated with polycystic kidney disease
8) Confidence 0.25 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.36 Pain Relevance 0.12
METHODS: The study group was 2868 consecutive patients who had their PC1 during a 30-month period.
Positive_regulation (had) of PC1
9) Confidence 0.19 Published 2008 Journal J Palliat Med Section Body Doc Link 18370893 Disease Relevance 0.28 Pain Relevance 0

General Comments

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