INT150835

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.62
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gper, Prkce) endoplasmic reticulum (Gper, Prkce) plasma membrane (Gper, Prkce)
mitochondrion (Prkce) enzyme binding (Prkce) cytoplasm (Prkce)
Anatomy Link Frequency
neurons 2
Gper (Rattus norvegicus)
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 12 100.00 Very High Very High Very High
antagonist 2 94.48 High High
Hyperalgesia 8 88.88 High High
nociceptor 2 70.64 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 98.52 Very High Very High Very High
Hyperalgesia 8 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found estrogen-induced as well as GPR30-agonist-induced PKCepsilon translocation to be restricted to the subgroup of nociceptive neurons positive for isolectin IB4 from Bandeiraea simplicifolia.
GPR30 Positive_regulation (agonist-induced) of Localization (translocation) of PKCepsilon in neurons associated with nociception and agonist
1) Confidence 0.15 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18371086 Disease Relevance 0.33 Pain Relevance 0.67
In contrast, G-1, a specific agonist of the recently identified G-protein-coupled estrogen receptor, GPR30, induced PKCepsilon translocation.
GPR30 Positive_regulation (induced) of Localization (translocation) of PKCepsilon associated with agonist
2) Confidence 0.14 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18371086 Disease Relevance 0.29 Pain Relevance 0.51

General Comments

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