INT150852

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.82
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
granulocytes 4
d cells 2
Cxcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 98 100.00 Very High Very High Very High
chemokine 44 100.00 Very High Very High Very High
Inflammation 78 97.42 Very High Very High Very High
guanethidine 6 91.20 High High
Inflammatory response 20 90.56 High High
Inflammatory mediators 22 82.48 Quite High
nociceptor 3 25.00 Low Low
fibrosis 1 24.56 Low Low
metalloproteinase 102 5.00 Very Low Very Low Very Low
COX-2 inhibitor 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 114 99.22 Very High Very High Very High
Herpes Simplex Virus 238 99.02 Very High Very High Very High
INFLAMMATION 114 97.42 Very High Very High Very High
Nociception 3 76.12 Quite High
Hypersensitivity 3 75.00 Quite High
Apoptosis 8 74.80 Quite High
Chlamydia Infection 48 58.32 Quite High
Disease 9 55.00 Quite High
Sarcoma 79 50.00 Quite Low
Targeted Disruption 3 40.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased secretion of the chemokines CXCL1 and CCL20 is particularly important for attracting granulocytes to sites of infection [29].
Positive_regulation (increased) of Localization (secretion) of CXCL1 in granulocytes associated with chemokine and infection
1) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.63 Pain Relevance 0.29
The increased secretion of the chemokines CXCL1 and CCL20 is particularly important for attracting granulocytes to sites of infection [29].
Positive_regulation (important) of Localization (secretion) of CXCL1 in granulocytes associated with chemokine and infection
2) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.64 Pain Relevance 0.30
Consistently, antigen challenge induced a time-dependent release of TNF-alpha, IL-1beta and KC/CXCL-1 in IM, but not in SI, mice.
Positive_regulation (time-dependent) of Localization (release) of CXCL-1
3) Confidence 0.49 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.23
Consistently, antigen challenge induced a time-dependent release of TNF-alpha, IL-1beta and KC/CXCL-1 in IM, but not in SI, mice.
Neg (not) Positive_regulation (induced) of Localization (release) of CXCL-1
4) Confidence 0.49 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.23
Together, these results suggest that inflammation associated with an adaptive immune response induces hypernociception that is mediated by an initial release of TNF-alpha, which triggers the subsequent release of IL-1beta and KC/CXCL1.
Positive_regulation (triggers) of Localization (release) of CXCL1 associated with inflammation
5) Confidence 0.49 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.17 Pain Relevance 0.23
Compared to uninfected HMVEC-d cells, KSHV infection triggered an appreciable (1.5-2) fold induction in the secretion of pro-ICs, such as growth regulated oncogene (GRO), GRO?
Positive_regulation (induction) of Localization (secretion) of GRO in d cells associated with herpes simplex virus, infection and cytokine
6) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.82 Pain Relevance 0.43

General Comments

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