INT150854

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.12
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr2) plasma membrane (Cxcr2) intracellular (Cxcr2)
signal transducer activity (Cxcr2)
Anatomy Link Frequency
lung 2
neutrophil 2
kidney 1
Cxcr2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 132 100.00 Very High Very High Very High
Inflammation 247 94.32 High High
antagonist 22 88.44 High High
cytokine 73 75.00 Quite High
corticosteroid 22 73.48 Quite High
guanethidine 2 53.04 Quite High
imagery 27 50.00 Quite Low
Infliximab 4 49.20 Quite Low
fibrosis 26 33.76 Quite Low
Inflammatory response 22 27.56 Quite Low
Disease Link Frequency Relevance Heat
Lung Injury 120 98.70 Very High Very High Very High
Hyperoxia 4 97.76 Very High Very High Very High
Rheumatoid Arthritis 5 96.60 Very High Very High Very High
Aspergillus Infection 43 96.44 Very High Very High Very High
Pulmonary Disease 171 95.80 Very High Very High Very High
Injury 199 95.28 Very High Very High Very High
Pneumonia 37 95.12 Very High Very High Very High
Pneumovirus Infections 3 90.40 High High
Infection 96 85.88 High High
Sprains And Strains 19 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of CXCR2 inhibits infiltration of neutrophils and attenuates dsRNA-induced lung injury
Negative_regulation (Inhibition) of CXCR2 in lung associated with lung injury
1) Confidence 0.54 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.44 Pain Relevance 0.07
The present study extends these findings by first determining the effects of high-dose intratracheal dsRNA alone on neutrophil recruitment and lung injury in BALB/c mice and then subsequently blocking these effects via inhibition of the CXC chemokine receptor, CXCR2.
Negative_regulation (inhibition) of CXCR2 in lung associated with lung injury and chemokine
2) Confidence 0.54 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.64 Pain Relevance 0.19
The anti-CXCR2 antibodies have been used previously to block mouse CXCR2 in vivo, and has been shown to detect CXCR2 by Western blot and fluorescence-activated cell sorting analysis of neutrophils in vivo [24-26,32].
Negative_regulation (block) of CXCR2 in neutrophils
3) Confidence 0.40 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.24 Pain Relevance 0.03
In a rat model of renal transplantation, repertaxin, a CXCR2 inhibitor, prevents granulocyte infiltration in the kidney and prevents deterioration of kidney function [65].
Negative_regulation (inhibitor) of CXCR2 in kidney
4) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.95 Pain Relevance 0.16
Hypernociception induced by antigen was reduced in animals pretreated with IL-1ra and reparixin (a non-competitive allosteric inhibitor of CXCR2), and in TNF receptor type 1 deficient (TNFR1-/-) mice.
Negative_regulation (inhibitor) of CXCR2
5) Confidence 0.34 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.23 Pain Relevance 0.18
This assumption is supported by two previous studies, which have reported that mice deficient in the chemokine receptor CXCR2 (CXCR2-/- mice) display a defect in neutrophil recruitment and were more susceptible to IA [36,35].
Negative_regulation (deficient) of CXCR2 in neutrophil associated with chemokine and aspergillus infection
6) Confidence 0.33 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2859869 Disease Relevance 0.74 Pain Relevance 0.16
SB-265610 is a small molecule inhibiting CXCR2.
Negative_regulation (inhibiting) of CXCR2
7) Confidence 0.27 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.88 Pain Relevance 0.26

General Comments

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