INT150856

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 6.97
Pain Relevance 4.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
stromal cells 2
d cells 2
granulocytes 1
immune cells 1
liver 1
Cxcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 428 100.00 Very High Very High Very High
Inflammation 324 100.00 Very High Very High Very High
chemokine 175 100.00 Very High Very High Very High
metalloproteinase 207 94.80 High High
Inflammatory response 72 93.08 High High
Inflammatory mediators 46 92.80 High High
guanethidine 6 90.24 High High
antagonist 3 84.80 Quite High
Inflammatory stimuli 23 48.00 Quite Low
fibrosis 3 25.04 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 443 100.00 Very High Very High Very High
Infection 270 98.88 Very High Very High Very High
Herpes Simplex Virus 476 98.68 Very High Very High Very High
Sprains And Strains 94 93.84 High High
Reprotox - General 3 24 90.56 High High
Adhesions 128 89.84 High High
Chlamydia Infection 236 89.24 High High
Cancer 142 87.68 High High
Disease 44 77.80 Quite High
Nociception 3 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results suggest that inflammation associated with an adaptive immune response induces hypernociception that is mediated by an initial release of TNF-alpha, which triggers the subsequent release of IL-1beta and KC/CXCL1.
Localization (release) of CXCL1 associated with inflammation
1) Confidence 0.78 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.17 Pain Relevance 0.22
Antigen-induced release of IL-1beta and KC/CXCL1 was reduced in TNFR1-/- mice, and TNF-alpha-induced hypernociception was inhibited by IL-1ra and reparixin.
Localization (release) of CXCL1
2) Confidence 0.78 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.24
Consistently, antigen challenge induced a time-dependent release of TNF-alpha, IL-1beta and KC/CXCL-1 in IM, but not in SI, mice.
Localization (release) of CXCL-1
3) Confidence 0.78 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.23
The increased secretion of the chemokines CXCL1 and CCL20 is particularly important for attracting granulocytes to sites of infection [29].
Localization (secretion) of CXCL1 in granulocytes associated with chemokine and infection
4) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.63 Pain Relevance 0.29
Furthermore, purified populations of endometrial cells from the WT mice secreted IL-6, CXCL1, CCL20 and PGE in response to LPS, in a dose and time dependent manner.
Localization (secreted) of CXCL1
5) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.53 Pain Relevance 0.14
As the mouse does not produce IL-8, measurement of mouse KC, a functional homolog of human IL-8 [18], could give us some information regarding a role of this pro-inflammatory cytokine in mediating BCG responses.
Localization (measurement) of KC associated with chemokine, inflammation and cytokine
6) Confidence 0.54 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.34 Pain Relevance 0.53
Binding of LPS to TLR4 on immune cells stimulates secretion of pro-inflammatory cytokines such as IL-6, chemokines such as CXCL1 and CCL20, and prostaglandin E2.
Localization (secretion) of CXCL1 in immune cells associated with chemokine, inflammation and cytokine
7) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943929 Disease Relevance 0.59 Pain Relevance 0.23
This lack of response to LPS was not due to a wider defect in innate immunity because TLR1, TLR2 and TLR9 ligands stimulated secretion of IL-6, CXCL1, CCL20 and PGE from endometrial cells purified from Tlr4?
Localization (secretion) of CXCL1
8) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.16 Pain Relevance 0.13
KC is a potent neutrophil chemoattractant that can be secreted by neutrophils, epithelial cells, endothelial cells, smooth muscle cells, fibroblasts, macrophages, platelets, and lymphocytes [39].
Localization (secreted) of KC in neutrophil associated with chemokine
9) Confidence 0.51 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.34 Pain Relevance 0.62
Interleukin 8 along with chemokines (Cxcl6, Cxcl1) released by 4T1 are chemotactic for neutrophils [20,21].
Localization (released) of Cxcl1 in 4T1 associated with chemokine
10) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.78 Pain Relevance 0.18
Endometrial epithelial or stromal cells from wild type but not Toll-like receptor 4 (TLR4) null mice secreted prostaglandin E2 and chemokine (C-X-C motif) ligand 1 (CXCL1) in response to LPS from EnPEC, highlighting the key role of LPS in PID.


Localization (secreted) of CXCL1 in stromal cells associated with chemokine
11) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2820550 Disease Relevance 0.29 Pain Relevance 0.09
Endometrial cells isolated from wild type mice also secreted PGE and the chemokine CXCL1, which is the murine chemokine similar to IL-8, in response to LPS from EnPEC but not more than the ultrapure LPS.
Neg (not) Localization (secreted) of CXCL1 associated with chemokine
12) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820550 Disease Relevance 0.36 Pain Relevance 0.18
Among the members of this family, IL-17A is the most studied, and it is secreted by activated T cells and acts on stromal cells to produce pro-inflammatory cytokines, such as GM-CSF, G-CSF, CXCL1, and CXCL8 (IL-8) [44].
Localization (secreted) of CXCL1 in stromal cells associated with inflammation and cytokine
13) Confidence 0.23 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.44 Pain Relevance 0.58
In acceptance and rejection liver transplant models, we measured KC FasL mRNA and protein using RT-PCR and Western blotting, respectively.
Localization (measured) of KC in liver
14) Confidence 0.12 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0 Pain Relevance 0
Compared to uninfected HMVEC-d cells, KSHV infection triggered an appreciable (1.5-2) fold induction in the secretion of pro-ICs, such as growth regulated oncogene (GRO), GRO?
Localization (secretion) of GRO in d cells associated with herpes simplex virus, infection and cytokine
15) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.82 Pain Relevance 0.43
Compared to uninfected HMVEC-d cells, KSHV infection triggered an appreciable (1.5-2) fold induction in the secretion of pro-ICs, such as growth regulated oncogene (GRO), GRO?
Localization (secretion) of GRO in d cells associated with herpes simplex virus, infection and cytokine
16) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.82 Pain Relevance 0.43
At a much lower level a similar effect was observed for GRO, G-CSF, IL-8, IL-1?
Localization (observed) of GRO
17) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2923116 Disease Relevance 0.15 Pain Relevance 0.37

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox