INT150867

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2011
Negated 5
Speculated 11
Reported most in Body
Documents 54
Total Number 64
Disease Relevance 71.38
Pain Relevance 8.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 6
nasal 2
glands 2
respiratory 2
neutrophil 2
COPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1484 100.00 Very High Very High Very High
depression 69 100.00 Very High Very High Very High
corticosteroid 229 99.52 Very High Very High Very High
Inflammatory response 116 98.56 Very High Very High Very High
Inflammatory stimuli 5 98.22 Very High Very High Very High
cytokine 258 95.24 Very High Very High Very High
nud 6 93.40 High High
Earache 6 92.88 High High
Paracetamol 3 91.36 High High
headache 31 91.20 High High
Disease Link Frequency Relevance Heat
Pulmonary Disease 3999 100.00 Very High Very High Very High
INFLAMMATION 1630 100.00 Very High Very High Very High
Cough 718 100.00 Very High Very High Very High
Influenza Virus Infection 594 100.00 Very High Very High Very High
Asthma 486 100.00 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 402 100.00 Very High Very High Very High
Dyspnea 364 100.00 Very High Very High Very High
Depression 77 100.00 Very High Very High Very High
Obesity 139 99.92 Very High Very High Very High
Bronchitis 139 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initially the COPD specific microarray chip would be arrayed with antibodies, oligonucleotides and antigens as there is evidence of their ligands (proteins, RNA and antibodies respectively) being dysregulated in COPD [55,195-197].
Regulation (dysregulated) of COPD associated with pulmonary disease
1) Confidence 0.48 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0.93 Pain Relevance 0.06
Role of influenza in stable COPD and in exacerbations
Regulation (Role) of COPD associated with pulmonary disease and influenza virus infection
2) Confidence 0.42 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692115 Disease Relevance 1.89 Pain Relevance 0.27
Consequences of cough in COPD
Regulation (cough) of COPD associated with pulmonary disease and cough
3) Confidence 0.39 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707150 Disease Relevance 1.78 Pain Relevance 0
Quantifying cough in COPD
Regulation (cough) of COPD associated with pulmonary disease and cough
4) Confidence 0.39 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707150 Disease Relevance 1.22 Pain Relevance 0
Effects of treatments on cough in COPD
Regulation (Effects) of COPD associated with pulmonary disease and cough
5) Confidence 0.39 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707150 Disease Relevance 1.80 Pain Relevance 0.10
FINDINGS: Daily life for people with COPD is affected in several different ways.
Regulation (affected) of COPD
6) Confidence 0.39 Published 2008 Journal J Adv Nurs Section Body Doc Link 18373613 Disease Relevance 0.22 Pain Relevance 0
Indeed, the fact that most COPD patients respond significantly to a bronchodilator provides the major rationale for the recommendation of bronchodilators as the mainstay of therapy for COPD.
Regulation (respond) of COPD associated with pulmonary disease
7) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC2991288 Disease Relevance 1.20 Pain Relevance 0.07
Salmeterol has more consistently demonstrated a significant effect on COPD exacerbation rate, which may reflect the study designs used [57].
Regulation (effect) of COPD associated with pulmonary disease
8) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC2991288 Disease Relevance 0.34 Pain Relevance 0.04
Nevertheless, their exact role in COPD management remains uncertain.
Regulation (role) of COPD associated with pulmonary disease
9) Confidence 0.36 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650603 Disease Relevance 0.77 Pain Relevance 0.19
Pierrou and colleagues have identified a gene set of 200 transcripts dysregulated in COPD compared to healthy smokers [37].
Regulation (dysregulated) of COPD associated with nicotine addiction and pulmonary disease
10) Confidence 0.35 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0.97 Pain Relevance 0
Influenza activity was an independent significant factor affecting hospital admission rates for COPD but not for asthma (Yap et al 2004).
Neg (not) Regulation (affecting) of COPD associated with asthma, pulmonary disease and influenza virus infection
11) Confidence 0.34 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692119 Disease Relevance 2.12 Pain Relevance 0
COPD is a major global epidemic affecting 5%–15% of all adults in industrialized countries (Pauwels et al 2001), normally presenting after the age of 50.
Regulation (affecting) of COPD associated with chronic obstructive pulmonary disease
12) Confidence 0.33 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650593 Disease Relevance 1.54 Pain Relevance 0.03
A new Community COPD Service was introduced in May 2009, to manage people with early stage COPD for up to eight weeks following hospital discharge.
Spec (May) Regulation (introduced) of COPD associated with pulmonary disease
13) Confidence 0.33 Published 2011 Journal Trials Section Body Doc Link PMC3024953 Disease Relevance 0.87 Pain Relevance 0
There is a need for randomised controlled trials to explore which exercise protocols are most effective for COPD patients.
Regulation (effective) of COPD associated with pulmonary disease
14) Confidence 0.33 Published 2004 Journal BMC Pulm Med Section Body Doc Link PMC514611 Disease Relevance 0.30 Pain Relevance 0.07
Hyperinflation and its management in COPD

Chronic obstructive pulmonary disease (COPD) is characterized by poorly reversible airflow limitation.

Regulation (characterized) of COPD associated with chronic obstructive pulmonary disease
15) Confidence 0.32 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Title Doc Link PMC2707802 Disease Relevance 0.76 Pain Relevance 0.05
The relatively rapid shallow breathing pattern in COPD compared with healthy subjects, reflects the mechanical constraints on tidal volume expansion, which has an exaggerated frequency-dependency in COPD, fR increases with exercise in COPD up to a maximum of about 25–35min?
Regulation (dependency) of COPD associated with chronic obstructive pulmonary disease
16) Confidence 0.32 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707802 Disease Relevance 0.36 Pain Relevance 0.08
Hyperinflation and its management in COPD

Chronic obstructive pulmonary disease (COPD) is characterized by poorly reversible airflow limitation.

Regulation (characterized) of COPD associated with chronic obstructive pulmonary disease
17) Confidence 0.32 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Title Doc Link PMC2707802 Disease Relevance 0.76 Pain Relevance 0.05
In a placebo-controlled trial of 1,411 patients with stable COPD, roflumilast 500 ?
Regulation (controlled) of COPD associated with pulmonary disease
18) Confidence 0.32 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873624 Disease Relevance 1.59 Pain Relevance 0.50
In a randomized clinical trial, Wongsurakiat and colleagues (2004) demonstrated that influenza vaccination is highly effective in the prevention of acute respiratory illness related to influenza virus infection, regardless of severity of COPD, comorbid diseases, age, gender, or smoking status.
Regulation (effective) of COPD in respiratory associated with nicotine addiction, pulmonary disease, influenza virus infection and disease
19) Confidence 0.31 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692115 Disease Relevance 1.55 Pain Relevance 0
The role of anticholinergics in COPD
Regulation (role) of COPD associated with pulmonary disease
20) Confidence 0.30 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692120 Disease Relevance 0.48 Pain Relevance 0.13

General Comments

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