INT150869

Context Info Confidence 0.70 First Reported 2008 Last Reported 2010 Negated 1 Speculated 1 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 3.78 Pain Relevance 2.20

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah) cytoplasm (Faah)

Anatomy Link Frequency sciatic nerve 2 intestine 2 Faah (Mus musculus)

Pain Link Frequency Relevance Heat Cannabinoid receptor 9 100.00 Spinal cord 23 99.28 Sciatic nerve 10 98.72 Endocannabinoid 33 96.40 Cannabinoid 19 95.04 antagonist 9 93.68 Dorsal horn 13 90.80 Glutamate 16 87.92 qutenza 10 87.24 Inflammation 20 85.64

Disease Link Frequency Relevance Heat Sepsis 40 100.00 Ileus 16 100.00 Nervous System Injury 34 98.40 INFLAMMATION 20 85.64 Neuropathic Pain 32 83.64 Nociception 13 53.84 Toxicity 7 25.88 Pain 13 5.00 Injury 11 5.00 Disease 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sepsis was associated with a selective upregulation of intestinal CB(1) receptors without affecting CB(2) receptor expression and with increased FAAH expression.

Neg (without) Positive_regulation (increased) of Gene_expression (expression) of FAAH associated with sepsis

1) Confidence 0.70 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.74 Pain Relevance 0.29

The increase in FAAH expression was completely reversed by cannabidiol but not affected by AM251.

Positive_regulation (increase) of Gene_expression (expression) of FAAH

2) Confidence 0.70 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.73 Pain Relevance 0.29

Sepsis was associated with a selective upregulation of intestinal CB(1) receptors without affecting CB(2) receptor expression and with increased FAAH expression.

Positive_regulation (upregulation) of Gene_expression (expression) of FAAH associated with sepsis

3) Confidence 0.50 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.87 Pain Relevance 0.30

Because of the therapeutic potential of cannabidiol in several pathologies, we investigated its effect on sepsis-induced ileus and on cannabinoid receptor and FAAH expression in the mouse intestine.

Spec (investigated) Positive_regulation (sepsis-induced) of Gene_expression (expression) of FAAH in intestine associated with ileus, cannabinoid receptor and sepsis

4) Confidence 0.50 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 1.06 Pain Relevance 0.30

In a microarray screen of gene regulation in the DRGs and spinal cord, we found a long lasting upregulation of FAAH expression in the DRGs in three models of sciatic nerve injury (Fig. 3 a) associated with a drop of endocannabinoids.

Positive_regulation (on) of Gene_expression (on) of FAAH in sciatic nerve associated with endocannabinoid, nervous system injury, sciatic nerve and spinal cord

5) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 0.39 Pain Relevance 1.03

General Comments

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