INT150869

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.78
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
sciatic nerve 2
intestine 2
Faah (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 9 100.00 Very High Very High Very High
Spinal cord 23 99.28 Very High Very High Very High
Sciatic nerve 10 98.72 Very High Very High Very High
Endocannabinoid 33 96.40 Very High Very High Very High
Cannabinoid 19 95.04 Very High Very High Very High
antagonist 9 93.68 High High
Dorsal horn 13 90.80 High High
Glutamate 16 87.92 High High
qutenza 10 87.24 High High
Inflammation 20 85.64 High High
Disease Link Frequency Relevance Heat
Sepsis 40 100.00 Very High Very High Very High
Ileus 16 100.00 Very High Very High Very High
Nervous System Injury 34 98.40 Very High Very High Very High
INFLAMMATION 20 85.64 High High
Neuropathic Pain 32 83.64 Quite High
Nociception 13 53.84 Quite High
Toxicity 7 25.88 Quite Low
Pain 13 5.00 Very Low Very Low Very Low
Injury 11 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sepsis was associated with a selective upregulation of intestinal CB(1) receptors without affecting CB(2) receptor expression and with increased FAAH expression.
Neg (without) Positive_regulation (increased) of Gene_expression (expression) of FAAH associated with sepsis
1) Confidence 0.70 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.74 Pain Relevance 0.29
The increase in FAAH expression was completely reversed by cannabidiol but not affected by AM251.
Positive_regulation (increase) of Gene_expression (expression) of FAAH
2) Confidence 0.70 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.73 Pain Relevance 0.29
Sepsis was associated with a selective upregulation of intestinal CB(1) receptors without affecting CB(2) receptor expression and with increased FAAH expression.
Positive_regulation (upregulation) of Gene_expression (expression) of FAAH associated with sepsis
3) Confidence 0.50 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.87 Pain Relevance 0.30
Because of the therapeutic potential of cannabidiol in several pathologies, we investigated its effect on sepsis-induced ileus and on cannabinoid receptor and FAAH expression in the mouse intestine.
Spec (investigated) Positive_regulation (sepsis-induced) of Gene_expression (expression) of FAAH in intestine associated with ileus, cannabinoid receptor and sepsis
4) Confidence 0.50 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 1.06 Pain Relevance 0.30
In a microarray screen of gene regulation in the DRGs and spinal cord, we found a long lasting upregulation of FAAH expression in the DRGs in three models of sciatic nerve injury (Fig. 3 a) associated with a drop of endocannabinoids.
Positive_regulation (on) of Gene_expression (on) of FAAH in sciatic nerve associated with endocannabinoid, nervous system injury, sciatic nerve and spinal cord
5) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 0.39 Pain Relevance 1.03

General Comments

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