INT150870

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.65
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
sciatic nerve 2
intestine 2
Faah (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 39 100.00 Very High Very High Very High
Cannabinoid receptor 17 100.00 Very High Very High Very High
Analgesic 21 99.98 Very High Very High Very High
depression 38 98.96 Very High Very High Very High
Sciatic nerve 10 98.72 Very High Very High Very High
Cannabinoid 44 98.12 Very High Very High Very High
Endocannabinoid 82 96.40 Very High Very High Very High
Pain 30 94.76 High High
analgesia 10 93.52 High High
Glutamate 18 91.00 High High
Disease Link Frequency Relevance Heat
Sepsis 10 100.00 Very High Very High Very High
Ileus 4 100.00 Very High Very High Very High
Depression 38 98.96 Very High Very High Very High
Nervous System Injury 35 98.40 Very High Very High Very High
Pain 40 94.76 High High
Neuropathic Pain 61 86.72 High High
INFLAMMATION 22 86.04 High High
Injury 19 80.96 Quite High
Inflammatory Pain 9 78.28 Quite High
Nociception 28 56.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the therapeutic potential of cannabidiol in several pathologies, we investigated its effect on sepsis-induced ileus and on cannabinoid receptor and FAAH expression in the mouse intestine.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of FAAH in intestine associated with ileus, cannabinoid receptor and sepsis
1) Confidence 0.45 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 1.06 Pain Relevance 0.30
Role of PPARs in mediating analgesic effects of FAAH inhibition
Regulation (effects) of Neg (inhibition) Gene_expression (inhibition) of FAAH associated with analgesic
2) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 0.39 Pain Relevance 0.99
In contrast, blockade of the Fatty Acid Amide Hydrolase, the enzyme that breaks anandamide down, with the specific inhibitor URB597 (2 ┬ÁM) had no effect (Fig 6D).
Neg (no) Regulation (effect) of Gene_expression (blockade) of Fatty Acid Amide Hydrolase
3) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.79 Pain Relevance 0.43
In a microarray screen of gene regulation in the DRGs and spinal cord, we found a long lasting upregulation of FAAH expression in the DRGs in three models of sciatic nerve injury (Fig. 3 a) associated with a drop of endocannabinoids.
Regulation (ne regulat) of Gene_expression (on) of FAAH in sciatic nerve associated with endocannabinoid, nervous system injury, sciatic nerve and spinal cord
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 0.40 Pain Relevance 1.16

General Comments

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