INT150875

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.72
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) enzyme binding (Alb) DNA binding (Alb)
protein complex (Alb) response to stress (Alb) cytoplasm (Alb)
Anatomy Link Frequency
leukocyte 2
hepatocytes 2
Alb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 3 82.00 Quite High
Inflammation 79 75.40 Quite High
Paracetamol 1 75.00 Quite High
Kinase C 2 74.20 Quite High
cytokine 20 72.80 Quite High
ischemia 7 70.64 Quite High
withdrawal 4 68.56 Quite High
agonist 14 65.04 Quite High
chemokine 13 48.64 Quite Low
Inflammatory response 11 11.84 Low Low
Disease Link Frequency Relevance Heat
Adhesions 56 99.40 Very High Very High Very High
Renal Disease 46 99.28 Very High Very High Very High
Death 19 96.36 Very High Very High Very High
Diabetes Mellitus 56 94.60 High High
Endotoxemia 3 93.60 High High
Sepsis 37 88.80 High High
Proteinuria 42 84.48 Quite High
Necrosis 3 82.92 Quite High
Cancer 42 82.56 Quite High
Cv Unclassified Under Development 43 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cells retained the characteristics of differentiated hepatocytes, but the functional characteristics such as albumin secretion, ureogenesis, and glyconeogenesis decreased gradually as the passages progressed beyond 200 population doublings (PDs).
Negative_regulation (decreased) of Localization (secretion) of albumin in hepatocytes
1) Confidence 0.35 Published 2008 Journal Transplant. Proc. Section Abstract Doc Link 18374145 Disease Relevance 0.15 Pain Relevance 0.07
In a study of rats given endotoxin by continuous infusion, fucoidin, a selectin-binding carbohydrate, blocked leukocyte adhesion but it did not significantly decrease leakage of albumin [26].
Neg (not) Negative_regulation (decrease) of Localization (leakage) of albumin in leukocyte associated with adhesions
2) Confidence 0.19 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 1.14 Pain Relevance 0.14
Albumin leakage was then determined as follows: ([FIout ?
Spec (determined) Negative_regulation (determined) of Spec (determined) Localization (leakage) of Albumin
3) Confidence 0.18 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.15 Pain Relevance 0.11
Increasing the dose of aliskiren to 300 mg/d further decreased albumin excretion to 20% by the end of the study.
Negative_regulation (decreased) of Localization (excretion) of albumin
4) Confidence 0.17 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.63 Pain Relevance 0.03
The albumin concentration was determined colorimetrically at 628 nm based on albumin binding to bromcresol green, using an albumin BCG diagnostic kit (Sigma Chemical Co., St.
Spec (determined) Negative_regulation (determined) of Localization (based) of albumin
5) Confidence 0.14 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 0.16 Pain Relevance 0.16
These 3 studies demonstrate that aliskiren alone or combined with an ARB reduced albumin excretion in patients with diabetic nephropathy, suggesting that direct renin inhibition may be an additional treatment option in patients with type 2 diabetes and nephropathy.
Negative_regulation (reduced) of Localization (excretion) of albumin associated with diabetes mellitus and renal disease
6) Confidence 0.13 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.50 Pain Relevance 0

General Comments

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