INT150887

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.74
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b, Il10) extracellular region (Il1b, Il10) aging (Il1b)
intracellular (Il10)
Anatomy Link Frequency
spinal cord 1
dorsal root ganglia 1
Il1b (Rattus norvegicus)
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 4 100.00 Very High Very High Very High
allodynia 2 100.00 Very High Very High Very High
Pain 6 98.48 Very High Very High Very High
Spinal cord 6 97.48 Very High Very High Very High
Eae 14 94.44 High High
Neuropathic pain 6 75.00 Quite High
Antihyperalgesic 4 75.00 Quite High
antiallodynic 4 75.00 Quite High
intrathecal 2 39.04 Quite Low
Analgesic 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 100.00 Very High Very High Very High
Hyperalgesia 4 100.00 Very High Very High Very High
Pain 2 98.48 Very High Very High Very High
Nervous System Injury 2 95.20 Very High Very High Very High
Injury 16 93.60 High High
Nociception 2 32.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the potential role of IL-1 in the pathogenesis of allodynia and hyperalgesia, IL-1alpha and comparative IL-1beta, IL-6, and IL-10 mRNA levels were quantified using competitive RT-PCR of the lumbar spinal cord and dorsal root ganglia (DRG; L5-L6) three and seven days after chronic constriction injury (CCI) in rats.
IL-1beta Regulation (role) of IL-10 mRNA in spinal cord associated with hyperalgesia, allodynia, eae, injury and spinal cord
1) Confidence 0.04 Published 2008 Journal Pain Section Abstract Doc Link 18374486 Disease Relevance 0.87 Pain Relevance 0.74
To study the potential role of IL-1 in the pathogenesis of allodynia and hyperalgesia, IL-1alpha and comparative IL-1beta, IL-6, and IL-10 mRNA levels were quantified using competitive RT-PCR of the lumbar spinal cord and dorsal root ganglia (DRG; L5-L6) three and seven days after chronic constriction injury (CCI) in rats.
IL-1beta Regulation (role) of IL-10 mRNA in dorsal root ganglia associated with hyperalgesia, allodynia, eae, injury and spinal cord
2) Confidence 0.01 Published 2008 Journal Pain Section Abstract Doc Link 18374486 Disease Relevance 0.87 Pain Relevance 0.74

General Comments

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