INT15089

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2011
Negated 4
Speculated 4
Reported most in Abstract
Documents 48
Total Number 52
Disease Relevance 17.87
Pain Relevance 25.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
platelets 5
Caco-2 4
JAR 2
mitral valves 1
brain 1
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 373 100.00 Very High Very High Very High
fluoxetine 101 100.00 Very High Very High Very High
sSRI 84 100.00 Very High Very High Very High
5HT 54 100.00 Very High Very High Very High
antidepressant 44 100.00 Very High Very High Very High
Pain 225 99.84 Very High Very High Very High
monoamine 15 99.50 Very High Very High Very High
Fibrositis 38 99.00 Very High Very High Very High
medulla 9 99.00 Very High Very High Very High
Analgesic 144 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 271 99.84 Very High Very High Very High
Nicotine Addiction 350 99.32 Very High Very High Very High
Congenital Anomalies 21 99.28 Very High Very High Very High
Reprotox - General 1 6 99.26 Very High Very High Very High
Affective Disorder 16 99.16 Very High Very High Very High
Fibromyalgia 30 99.00 Very High Very High Very High
Disease 116 98.80 Very High Very High Very High
Migraine With Aura 4 98.80 Very High Very High Very High
Functional Bowel Disorder 9 98.72 Very High Very High Very High
INFLAMMATION 88 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, high-glucose levels modulate SERT activity.
Regulation (modulate) of SERT
1) Confidence 0.62 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 19000377 Disease Relevance 0 Pain Relevance 0.31
The chronic effect of SSRIs on the activity of the serotonin transporter (SERT) has been less studied and the results have been contradictory.
Regulation (effect) of SERT associated with serotonin and ssri
2) Confidence 0.59 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289086 Disease Relevance 0.18 Pain Relevance 0.71
The chronic effect of SSRIs on the activity of the serotonin transporter (SERT) has been less studied and the results have been contradictory.
Regulation (effect) of serotonin transporter associated with serotonin and ssri
3) Confidence 0.59 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289086 Disease Relevance 0.18 Pain Relevance 0.71
Fluoxetine affected mainly the hSERT transport rate by reducing the availability of the transporter in the membrane with no significant alteration of either the total hSERT protein content or the hSERT mRNA level.
Neg (no) Regulation (alteration) of hSERT associated with fluoxetine
4) Confidence 0.59 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289086 Disease Relevance 0.13 Pain Relevance 0.88
Fluoxetine affected mainly the hSERT transport rate by reducing the availability of the transporter in the membrane with no significant alteration of either the total hSERT protein content or the hSERT mRNA level.
Neg (no) Regulation (alteration) of hSERT protein associated with fluoxetine
5) Confidence 0.59 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289086 Disease Relevance 0.13 Pain Relevance 0.87
Moreover, chronic (48 h) exposure of cells to caffeine (1 microM) stimulated and chronic exposure to xanthohumol and iso-xanthohumol (1 and 0.1 microM, respectively) inhibited (3)H-thiamine uptake, these effects being not mediated through modulation of the expression levels of either hThTr-1 or hSERT mRNA.
Regulation (modulation) of hSERT
6) Confidence 0.58 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 16889681 Disease Relevance 0 Pain Relevance 0.28
Molecular characterization and intracellular regulation of the human serotonin transporter in Caco-2 cells.
Regulation (regulation) of serotonin transporter in Caco-2 associated with serotonin
7) Confidence 0.54 Published 2006 Journal J. Physiol. Pharmacol. Section Title Doc Link 16601320 Disease Relevance 0.19 Pain Relevance 0.20
The effect of high glucose on SERT, the human plasmalemmal serotonin transporter.
Regulation (effect) of serotonin transporter associated with serotonin
8) Confidence 0.54 Published 2008 Journal Nutr Neurosci Section Title Doc Link 19000377 Disease Relevance 0 Pain Relevance 0.29
The effect of high glucose on SERT, the human plasmalemmal serotonin transporter.
Regulation (effect) of SERT associated with serotonin
9) Confidence 0.54 Published 2008 Journal Nutr Neurosci Section Title Doc Link 19000377 Disease Relevance 0 Pain Relevance 0.29
SERT is modulated by differentiation events, implying that SERT density in platelets is under the control of megakaryocytopoiesis stages.
Regulation (modulated) of SERT in platelets
10) Confidence 0.54 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 20041293 Disease Relevance 0.28 Pain Relevance 0.13
Our previous studies demonstrated an alteration of SERT density and of the uptake rate of SERT in psychiatric patients [28,29].
Regulation (alteration) of SERT
11) Confidence 0.53 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779383 Disease Relevance 0.13 Pain Relevance 0.09
AIM: To study the influence of acute serotonin transporter inhibition on colonic sensorimotor function in man.
Regulation (influence) of serotonin transporter
12) Confidence 0.45 Published 2006 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 16393306 Disease Relevance 0.20 Pain Relevance 0
These findings support previous results suggesting that the 5-HTT gene is involved in the polygenic etiology of MA.
Regulation (involved) of 5-HTT associated with migraine with aura
13) Confidence 0.44 Published 2010 Journal Headache Section Abstract Doc Link 19845785 Disease Relevance 0.62 Pain Relevance 0.37
Fluoxetine affected mainly the hSERT transport rate by reducing the availability of the transporter in the membrane with no significant alteration of either the total hSERT protein content or the hSERT mRNA level.
Regulation (affected) of hSERT associated with fluoxetine
14) Confidence 0.44 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289086 Disease Relevance 0.14 Pain Relevance 0.88
To our knowledge, this is the first report of an influence of the 5-HTTLPR polymorphisms on pain sensitivity in humans.
Regulation (influence) of 5-HTTLPR associated with pain
15) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2717925 Disease Relevance 0.75 Pain Relevance 1.11
In this study, we used cell cultures of platelet precursors as models of investigation on mechanisms of SERT regulation: SERT expression was appraised during megakaryocytic differentiation of human megakaryoblastic MEG-01 cells.
Regulation (regulation) of SERT in platelet
16) Confidence 0.39 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 20041293 Disease Relevance 0.34 Pain Relevance 0.18
Our previous studies demonstrated an alteration of SERT density and of the uptake rate of SERT in psychiatric patients [28,29].
Regulation (alteration) of SERT
17) Confidence 0.38 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779383 Disease Relevance 0.13 Pain Relevance 0.12
The serotonin transporter (SERT) has shown itself to be an effective pharmacological target in the treatment of mood disorders and some kinds of gastrointestinal syndromes.
Regulation (target) of serotonin transporter associated with syndrome, affective disorder and serotonin
18) Confidence 0.27 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 16601320 Disease Relevance 0.20 Pain Relevance 0.09
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations.
Regulation (modulation) of serotonin transporter associated with serotonin
19) Confidence 0.27 Published 2004 Journal Mol. Interv. Section Abstract Doc Link 15087484 Disease Relevance 0.51 Pain Relevance 0.20
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations.
Regulation (modulation) of SERT associated with serotonin
20) Confidence 0.27 Published 2004 Journal Mol. Interv. Section Abstract Doc Link 15087484 Disease Relevance 0.51 Pain Relevance 0.20

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