INT150890

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.06
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1, Esr2) DNA binding (Esr1, Esr2) cytoplasm (Esr1, Esr2)
lipid binding (Esr1, Esr2) nucleus (Esr1, Esr2) plasma membrane (Esr1, Esr2)
Anatomy Link Frequency
neuronal 1
immune cells 1
Esr1 (Mus musculus)
Esr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 4 98.48 Very High Very High Very High
Pain 4 95.44 Very High Very High Very High
Inflammation 16 93.92 High High
Sciatic nerve 4 91.60 High High
Analgesic 1 84.76 Quite High
Stimulus evoked pain 2 81.84 Quite High
antagonist 6 61.36 Quite High
nociceptor 6 25.00 Low Low
cytokine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 6 98.48 Very High Very High Very High
Pain 4 95.44 Very High Very High Very High
Neurodegenerative Disease 2 95.04 Very High Very High Very High
INFLAMMATION 10 93.92 High High
Hypersensitivity 2 81.44 Quite High
Targeted Disruption 1 75.36 Quite High
Nervous System Injury 2 75.00 Quite High
Hyperalgesia 2 57.04 Quite High
Nociception 2 38.16 Quite Low
Non-diabetic Peripheral Neuropathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that the gene for ERalpha is associated with the sexual mechanisms (response to estrous female) and the genes for ERbeta and ERalpha with the social (recognition of novel female) mechanisms underlying the effects of female cues on male risk taking.
ERalpha Binding (associated) of ERbeta
1) Confidence 0.52 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18374493 Disease Relevance 0.08 Pain Relevance 0.08
Genistein binds estrogen receptors (ER) with higher affinity for the ERbeta particularly expressed in neuronal and immune cells.
ER Binding (affinity) of ERbeta in immune cells
2) Confidence 0.26 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18691380 Disease Relevance 0.99 Pain Relevance 0.61
Genistein binds estrogen receptors (ER) with higher affinity for the ERbeta particularly expressed in neuronal and immune cells.
ER Binding (affinity) of ERbeta in neuronal
3) Confidence 0.09 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18691380 Disease Relevance 0.99 Pain Relevance 0.61

General Comments

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