INT15090

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Context Info
Confidence 0.31
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.40
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ANTXR1)
ANTXR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 3 100.00 Very High Very High Very High
Serotonin 12 99.84 Very High Very High Very High
Morphine 7 99.08 Very High Very High Very High
tetrodotoxin 156 94.40 High High
addiction 48 73.28 Quite High
antidepressant 4 67.92 Quite High
local anesthetic 12 61.68 Quite High
fluoxetine 2 54.24 Quite High
Desipramine 2 52.40 Quite High
monoamine 2 46.96 Quite Low
Disease Link Frequency Relevance Heat
Vibrio Infection 18 100.00 Very High Very High Very High
Bordatella Infection 6 100.00 Very High Very High Very High
Stress 5 95.92 Very High Very High Very High
Reprotox - General 1 6 76.64 Quite High
Heart Arrhythmia 10 5.00 Very Low Very Low Very Low
Channelopathies 8 5.00 Very Low Very Low Very Low
Sudden Infant Death Syndrome 6 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of cholera toxin on serotonin transport is specific because, under similar conditions, cholera toxin inhibits 3-O-methyl-D-glucose transport and does not influence taurine transport in this cell line.
Regulation (effect) of cholera toxin associated with vibrio infection and serotonin
1) Confidence 0.31 Published 1991 Journal J. Biol. Chem. Section Abstract Doc Link 1714897 Disease Relevance 0.90 Pain Relevance 0.30
There is also no significant change in the protein content of the cells after cholera toxin treatment.
Neg (no) Regulation (change) of cholera toxin associated with vibrio infection
2) Confidence 0.16 Published 1991 Journal J. Biol. Chem. Section Abstract Doc Link 1714897 Disease Relevance 0.90 Pain Relevance 0.22
On the other hand, the “trapped ion” model does not require the assumption of a conformational change of the toxin receptor during gating.
Regulation (change) of toxin receptor
3) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.52
During depolarization, block development was complete after 0.2 ms and did not change over a period of 12 ms indicating that the affinity change of the toxin receptor was triggered by a rapid activation whereas subsequent inactivation did not result in further modification.
Regulation (change) of toxin receptor
4) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.35
To find whether the antipropulsive effect of morphine administered intracerebroventricularly (i.c.v.) depends on a G-protein-mediated mechanism, we studied the effect of i.c.v. pertussis toxin (PTX) pretreatment on morphine-induced inhibition of intestinal motility.
Regulation (effect) of pertussis toxin associated with bordatella infection and morphine
5) Confidence 0.01 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2160368 Disease Relevance 0.17 Pain Relevance 0.47
This study examined the potential role of testicular opioids, a pertussis toxin (PT)-sensitive G-protein, and phosphodiesterase in mediating the inhibitory effect of immobilization stress on testicular steroidogenesis in adult rats.
Spec (examined) Regulation (role) of pertussis toxin associated with stress, bordatella infection and opioid
6) Confidence 0.00 Published 1996 Journal J. Androl. Section Abstract Doc Link 8833736 Disease Relevance 0.43 Pain Relevance 0.17

General Comments

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