INT15091

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 101
Total Number 106
Disease Relevance 29.91
Pain Relevance 53.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
platelet 4
oocytes 4
intestine 3
JAR 3
SK-N-MC 3
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 917 100.00 Very High Very High Very High
depression 116 100.00 Very High Very High Very High
Dopamine 108 100.00 Very High Very High Very High
Neuropeptide 21 100.00 Very High Very High Very High
fluoxetine 147 99.92 Very High Very High Very High
spastic colon 44 99.82 Very High Very High Very High
Central nervous system 76 99.68 Very High Very High Very High
5HT 19 99.64 Very High Very High Very High
Potency 7 99.64 Very High Very High Very High
cocaine 15 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 129 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

89 99.82 Very High Very High Very High
Reprotox - General 1 14 99.78 Very High Very High Very High
Intellectual Impairment 1 99.68 Very High Very High Very High
Functional Bowel Disorder 35 99.60 Very High Very High Very High
Enteropathy 7 99.56 Very High Very High Very High
Malignant Neoplastic Disease 9 98.84 Very High Very High Very High
Stress 63 98.64 Very High Very High Very High
Colitis 3 98.64 Very High Very High Very High
Pain 1214 98.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results show that these cells express a SERT mRNA identical to the human brain SERT, and a 70 kDa protein immunodetected using a specific antibody.
Gene_expression (express) of SERT mRNA in brain
1) Confidence 0.78 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 16601320 Disease Relevance 0.18 Pain Relevance 0.18
In conclusion, these results suggest that human intestinal epithelial Caco-2 cells functionally express SERT, both at their apical and basolateral cell membranes.
Gene_expression (express) of SERT in Caco-2
2) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12682218 Disease Relevance 0 Pain Relevance 0.79
In summary, we have shown herein that control megakaryoblasts express the SERT protein.
Gene_expression (express) of SERT protein in megakaryoblasts
3) Confidence 0.78 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 20041293 Disease Relevance 0.29 Pain Relevance 0.13
In this study, we used cell cultures of platelet precursors as models of investigation on mechanisms of SERT regulation: SERT expression was appraised during megakaryocytic differentiation of human megakaryoblastic MEG-01 cells.
Gene_expression (expression) of SERT in platelet
4) Confidence 0.78 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 20041293 Disease Relevance 0.34 Pain Relevance 0.18
Function, expression, and characterization of the serotonin transporter in the native human intestine.
Gene_expression (expression) of serotonin transporter in intestine associated with serotonin
5) Confidence 0.78 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 17991706 Disease Relevance 0.09 Pain Relevance 0.15
Real-time PCR studies showed relatively higher SERT mRNA expression in the human small intestine compared with colon (ileum >> duodenum >> jejunum).
Gene_expression (expression) of SERT mRNA in small intestine
6) Confidence 0.78 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17991706 Disease Relevance 0.09 Pain Relevance 0.12
Notably, SERT expression was localized predominantly to the apical and intracellular compartments and was distributed throughout the crypt-villus axis.
Gene_expression (expression) of SERT in villus
7) Confidence 0.78 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17991706 Disease Relevance 0.07 Pain Relevance 0.20
Consistent with SERT mRNA expression, SERT immunostaining was mainly detected in the epithelial cells of human duodenal and ileal resected tissues.
Gene_expression (expression) of SERT mRNA in epithelial cells
8) Confidence 0.78 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17991706 Disease Relevance 0.08 Pain Relevance 0.14
Current studies were designed to characterize the function, expression, distribution, and membrane localization of SERT in the native human intestine.
Gene_expression (expression) of SERT in intestine
9) Confidence 0.78 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17991706 Disease Relevance 0.09 Pain Relevance 0.13
Our studies demonstrated differential expression of SERT across various regions of the human intestine and provide evidence for the existence of a functional SERT capable of removing intraluminal serotonin in human ileal epithelial cells.
Gene_expression (expression) of SERT in epithelial cells associated with serotonin
10) Confidence 0.78 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17991706 Disease Relevance 0 Pain Relevance 0.22
There is also evidence that changes in the expression of SERT are due to a polymorphism in the transcription region in patients with FM [19].
Gene_expression (expression) of SERT
11) Confidence 0.76 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779383 Disease Relevance 0.39 Pain Relevance 0.44
RESULTS: hSERT-expressing oocytes were perfused with 10 micromol/L serotonin (5-HT) to induce hSERT-current.
Gene_expression (expressing) of hSERT in oocytes
12) Confidence 0.76 Published 2006 Journal Acta Pharmacol. Sin. Section Body Doc Link 16490163 Disease Relevance 0 Pain Relevance 0
METHODS: Tegaserod inhibition of SERT-mediated [3H]5-HT and NET- and DAT-mediated [3H]dopamine uptake was measured in human embryonic kidney (HEK) 293 cells stably expressing hSERT, hDAT, and hNET in comparison with untransfected control HEK293-FT cells.
Gene_expression (expressing) of hSERT in embryonic kidney
13) Confidence 0.76 Published 2007 Journal Digestion Section Body Doc Link 17510552 Disease Relevance 0 Pain Relevance 0
The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics.
Gene_expression (present) of SLC6A4 in B-cell associated with malignant neoplastic disease, cancer and serotonin
14) Confidence 0.75 Published 2005 Journal FASEB J. Section Title Doc Link 15870169 Disease Relevance 0.77 Pain Relevance 0.22
METHODS: The expression levels of TrKB, MOR and 5HTT mRNA in DIE were determined using laser capture microdissection and real-time RT-PCR techniques.
Gene_expression (expression) of 5HTT
15) Confidence 0.75 Published 2007 Journal Hum. Reprod. Section Body Doc Link 17000647 Disease Relevance 0.09 Pain Relevance 0
These results suggest that the effect of fluoxetine on the expression of hSERT is post-translational and has shown itself to be independent of PKC and PKA activity.
Gene_expression (expression) of hSERT associated with fluoxetine
16) Confidence 0.75 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289086 Disease Relevance 0.12 Pain Relevance 0.85
Using in-vitro binding assays at membranes from COS-1 cells expressing the human 5-HT transporter (hSERT) and in-vivo electrophysiological and microdialysis techniques in rats, the present study was directed at determining whether R-citalopram modifies the action of selective serotonin reuptake inhibitors (SSRIs) known to act on allosteric sites namely escitalopram, and to a lesser extent paroxetine, compared to fluoxetine, which has no affinity for these sites.
Gene_expression (expressing) of hSERT associated with ssri and fluoxetine
17) Confidence 0.74 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16448580 Disease Relevance 0 Pain Relevance 0.42
As JAR cells, as well as the placenta, express the neuronal serotonin transporter (SERT), a comparison between the uptake of (3)H-MPP(+) and (3)H-serotonin ((3)H-5HT) was made.
Gene_expression (express) of SERT in placenta associated with 5ht and serotonin
18) Confidence 0.68 Published 2003 Journal Placenta Section Abstract Doc Link 12657510 Disease Relevance 0.17 Pain Relevance 0.37
Current data on the efficacy of SSRIs in IBS, association of the SERT gene promoter polymorphism 5-HTTLPR with IBS and the expression pattern of SERT in the intestinal mucosa of IBS patients are conflicting.
Gene_expression (expression) of SERT associated with spastic colon and ssri
19) Confidence 0.68 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.25 Pain Relevance 1.04
Recent molecular studies have raised critical questions about multiple SERT mRNA transcripts in the human gut, the role of polymorphic SERT promoter in the regulation of enteric SERT expression and the ability of 5-HTTLPR to affect human SERT gene transcription.
Gene_expression (expression) of SERT in gut
20) Confidence 0.68 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.23 Pain Relevance 0.98

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