INT150931

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.23
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCH1) small molecule metabolic process (GCH1) nucleolus (GCH1)
nucleus (GCH1) protein complex assembly (GCH1) protein complex (GCH1)
Anatomy Link Frequency
white blood cells 2
GCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GCH1 47 100.00 Very High Very High Very High
Pain 74 99.76 Very High Very High Very High
backache 1 94.60 High High
Stimulus evoked pain 1 88.48 High High
Lasting pain 3 73.60 Quite High
Serotonin 1 72.08 Quite High
Tetrahydrobiopterin 5 67.76 Quite High
Hyperalgesia 3 50.00 Quite Low
Analgesic 5 15.68 Low Low
Sciatica 12 10.00 Low Low
Disease Link Frequency Relevance Heat
Pain 72 99.76 Very High Very High Very High
Heart Rate Under Development 1 97.12 Very High Very High Very High
Low Back Pain 1 94.60 High High
Dystonia 2 89.28 High High
Hypersensitivity 1 88.48 High High
Phenylketonuria 2 88.24 High High
Disease 2 84.76 Quite High
Inborn Genetic Diseases 1 72.92 Quite High
Hyperalgesia 3 50.00 Quite Low
Nerve Root Compression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The results strength the support for a modest yet reproducible and consistent pain-protective effect associated with a GCH1 haplotype known to reduce GCH1 and thus BH4 up-regulation.
Negative_regulation (reduce) of GCH1
1) Confidence 0.59 Published 2009 Journal Clin J Pain Section Body Doc Link 19851158 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: This study verifies previous results that decreased GCH1 function or inducibility as a result of genetic polymorphisms protects against pain.
Negative_regulation (decreased) of GCH1
2) Confidence 0.58 Published 2008 Journal Eur J Pain Section Body Doc Link 18374612 Disease Relevance 0 Pain Relevance 0
GCH1, BH4 and iNOS upregulation in white blood cells after lipopolysaccharide stimulation were decreased in carriers of the GCH1 haplotype, which verified that the genotype groups differed with respect to regulation of the biopterin pathway.
Negative_regulation (decreased) of GCH1 in white blood cells
3) Confidence 0.42 Published 2008 Journal Eur J Pain Section Body Doc Link 18374612 Disease Relevance 0.06 Pain Relevance 0
GCH1, BH4 and iNOS upregulation in white blood cells after lipopolysaccharide stimulation were decreased in carriers of the GCH1 haplotype, which verified that the genotype groups differed with respect to regulation of the biopterin pathway.
Negative_regulation (decreased) of GCH1 in white blood cells
4) Confidence 0.42 Published 2008 Journal Eur J Pain Section Body Doc Link 18374612 Disease Relevance 0.06 Pain Relevance 0
Here, we show that carriers of the pain-protective GCH1 haplotype also carry the c.*243C>T variant and vice versa.
Negative_regulation (carry) of GCH1 associated with pain and gch1
5) Confidence 0.41 Published 2008 Journal Mutat. Res. Section Abstract Doc Link 18515178 Disease Relevance 0.93 Pain Relevance 0.74
We found 3 haplotype blocks across GCH1 including its flanking region based on confidence interval method in European Americans and 5 blocks in African Americans with different size and different contributing SNPs.
Negative_regulation (blocks) of GCH1 associated with gch1
6) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC1821314 Disease Relevance 0.18 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox