INT150932

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.07
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCH1) small molecule metabolic process (GCH1) nucleolus (GCH1)
nucleus (GCH1) protein complex assembly (GCH1) protein complex (GCH1)
Anatomy Link Frequency
white blood cells 2
GCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GCH1 30 100.00 Very High Very High Very High
Tetrahydrobiopterin 10 100.00 Very High Very High Very High
Chronic pancreatitis 34 99.92 Very High Very High Very High
Neuropathic pain 5 98.80 Very High Very High Very High
Pain 110 96.88 Very High Very High Very High
Dopamine 37 92.80 High High
Visceral pain 7 88.56 High High
Pain score 1 85.04 High High
tolerance 1 72.60 Quite High
Catechol-O-methyltransferase 4 68.40 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 63 99.92 Very High Very High Very High
Neuropathic Pain 7 99.24 Very High Very High Very High
Pain 113 96.88 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

7 88.56 High High
Dyskinesias 15 83.12 Quite High
Disease 55 60.20 Quite High
Hyperalgesia 1 50.00 Quite Low
Nerve Root Compression 4 44.56 Quite Low
Dermatitis 1 31.12 Quite Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GCH1 expression was significantly increased in a rat model of peripheral neuropathic pain, and blocking GCH1 reduced the pain response [7].
Positive_regulation (increased) of Gene_expression (expression) of GCH1 associated with pain, neuropathic pain and gch1
1) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2626574 Disease Relevance 1.61 Pain Relevance 2.04
GCH1, iNOS upregulation and BH4 production were assessed ex-vivo in white blood cells after lipopolysaccharide stimulation for 24 h.
Positive_regulation (upregulation) of Gene_expression (production) of GCH1 in white blood cells
2) Confidence 0.46 Published 2008 Journal Eur J Pain Section Body Doc Link 18374612 Disease Relevance 0.09 Pain Relevance 0
Hence, in order to produce functional benefit, a combination of viral vectors expressing both GTP cyclohydrolase 1 (GCH1; a key enzyme in BH4 synthesis) and tyrosine hydroxylase is required.
Positive_regulation (required) of Gene_expression (expressing) of GCH1 associated with tetrahydrobiopterin and gch1
3) Confidence 0.29 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626922 Disease Relevance 0.20 Pain Relevance 0.53

General Comments

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