INT150933

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.80
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCH1) small molecule metabolic process (GCH1) nucleolus (GCH1)
nucleus (GCH1) protein complex assembly (GCH1) protein complex (GCH1)
GCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GCH1 10 100.00 Very High Very High Very High
Pain 150 99.18 Very High Very High Very High
Tetrahydrobiopterin 2 96.32 Very High Very High Very High
Sciatica 4 96.16 Very High Very High Very High
Opioid 11 94.24 High High
Cancer pain 3 89.36 High High
Hyperalgesia 3 75.00 Quite High
Catecholamine 1 74.68 Quite High
Serotonin 1 73.92 Quite High
nociceptor 5 70.40 Quite High
Disease Link Frequency Relevance Heat
Pain 153 99.18 Very High Very High Very High
Nerve Root Compression 1 96.16 Very High Very High Very High
Cancer 5 93.52 High High
Cancer Pain 3 89.36 High High
Hyperalgesia 3 75.00 Quite High
Nociception 11 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ex-vivo, GCH1 upregulation and BH4 production after forskolin stimulation were reduced, while baseline BH4 concentrations were not affected.
Negative_regulation (reduced) of Positive_regulation (upregulation) of GCH1
1) Confidence 0.58 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18374612 Disease Relevance 0.44 Pain Relevance 0.70
Thus, reduced GCH1 upregulation, here conferred by non-coding and non-splice site GCH1 variants known to lead to decreased tetrahydrobiopterin expression, delays the need for opioid therapy in cancer.
Negative_regulation (reduced) of Positive_regulation (upregulation) of GCH1 associated with tetrahydrobiopterin, cancer, gch1 and opioid
2) Confidence 0.43 Published 2010 Journal Pain Section Abstract Doc Link 19959292 Disease Relevance 0.59 Pain Relevance 0.74
Subjects heterozygous or
               homozygous for the pain-protective haplotype were found to show reduced upregulation
               of the GCH1 transcript in response to cAMP, resulting in lower
               levels of BH4, suggesting that altered GCH1 transcriptional
               modulation underlies the decreased pain sensitivity observed in these individuals.
Negative_regulation (reduced) of Positive_regulation (upregulation) of GCH1 associated with pain and gch1
3) Confidence 0.38 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.77 Pain Relevance 1.34

General Comments

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