INT150949

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Context Info
Confidence 0.63
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.71
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fgfr1) nucleus (Fgfr1) kinase activity (Fgfr1)
cytoplasm (Fgfr1)
Anatomy Link Frequency
skin 2
fibroblast 2
connective tissue 1
keratinocytes 1
PANC-1 1
Fgfr1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
cytokine 77 99.38 Very High Very High Very High
Inflammation 126 89.64 High High
cINOD 3 75.00 Quite High
psoriasis 47 70.40 Quite High
GABAergic 5 63.80 Quite High
Pyramidal cell 17 62.24 Quite High
chemokine 17 21.36 Low Low
rheumatoid arthritis 88 7.04 Low Low
Inflammatory mediators 7 5.72 Low Low
Disease Link Frequency Relevance Heat
Osteochondroma 40 98.92 Very High Very High Very High
Targeted Disruption 77 98.36 Very High Very High Very High
Chondrosarcoma 19 97.68 Very High Very High Very High
Pancreatic Cancer 57 97.60 Very High Very High Very High
Hypersensitivity 2 96.96 Very High Very High Very High
Cancer 64 96.52 Very High Very High Very High
Congenital Anomalies 37 94.64 High High
Death 16 93.76 High High
Systemic Sclerosis 34 91.52 High High
INFLAMMATION 138 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generation and maintenance of mice lacking FGFR1 and/or FGFR2 in keratinocytes
Neg (lacking) Gene_expression (/) of FGFR1 in keratinocytes
1) Confidence 0.63 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.76 Pain Relevance 0.14
FGFR1IIIb-deficient mice are phenotypically normal and do not display an obvious skin phenotype because only the IIIb exon of the Fgfr1 gene was deleted in these mice, whereas all other FGFR1 splice variants are normally expressed (Zhang et al., 2004).
Gene_expression (expressed) of FGFR1 in skin
2) Confidence 0.56 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.32 Pain Relevance 0
Real-time RT-PCR using RNA from isolated epidermis of control and mutant mice demonstrated a strong reduction of Fgfr1 and Fgfr2 expression (Fig. 1 B) in newborn single and double knockout mice, which further declined until postnatal day 18 (P18; Fig. 1 B and not depicted).
Gene_expression (expression) of Fgfr1 in epidermis associated with targeted disruption
3) Confidence 0.56 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.26 Pain Relevance 0
However, while more floxed alleles of genes expressed in the brain continue to be developed, including NR1, BDNF (Rios et al., 2001), the Adenosine A1 receptor (Scammell et al., 2003), Presenilin-1 (Yu et al., 2001), neuropilin-2 (Walz et al., 2002), and the fibroblast growth factor receptor 1 (Xu et al., 2002; Zhao et al., 2007), generating gene-targeted mice is time consuming.
Gene_expression (expressed) of fibroblast growth factor receptor 1 in fibroblast associated with adenocard
4) Confidence 0.46 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0 Pain Relevance 0.11
Cytokine or cytokine receptor patterns showed high expression of CCR1, FGFR1, connective tissue growth factor (CTGF), FGF7, and SCYA19 in biopsies from SSC patients.
Gene_expression (expression) of FGFR1 in connective tissue associated with hypersensitivity and cytokine
5) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.11 Pain Relevance 0.10
At the protein level, re-expression of several of these signalling molecules (FGF2, FGFR1, p21, PTHrP and Bcl-2) was found in secondary peripheral chondrosarcoma and the expression increased with increasing histological grade [94].
Gene_expression (expression) of FGFR1 associated with chondrosarcoma
6) Confidence 0.19 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 1.18 Pain Relevance 0
In addition, transfection of a truncated FGFR-1 into PANC-1 cells induces the blockade of FGF receptor-dependent pathways and reduces tumour growth in nude mice [28].
Gene_expression (transfection) of FGFR-1 in PANC-1 associated with cancer
7) Confidence 0.17 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.37 Pain Relevance 0
Lansoprazole favors mucosal cell renewal simultaneously by stimulating gene expression of prosurvival proliferating cell nuclear antigen, survivin, epidermal growth factor, and basic fibroblast growth factor.
Gene_expression (expression) of basic fibroblast growth factor in fibroblast
8) Confidence 0.02 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18375387 Disease Relevance 0.70 Pain Relevance 0.22

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