INT150959

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.21
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (BCO2) intracellular (BCO2)
Anatomy Link Frequency
chondrocytes 1
thyroid 1
BCO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 82.16 Quite High
COX-2 inhibitor 1 78.48 Quite High
Osteoarthritis 1 50.00 Quite Low
withdrawal 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 16 100.00 Very High Very High Very High
Thyroid Neoplasm 169 99.64 Very High Very High Very High
Cancer 101 93.80 High High
INFLAMMATION 3 92.80 High High
Hypertension 1 89.04 High High
Diarrhoea 3 88.36 High High
Disease 84 86.64 High High
Toxicity 2 78.96 Quite High
Disease Progression 1 77.96 Quite High
Liver Failure 1 54.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclo-oxygenase 2 (COX-2) is an enzyme overexpressed in many thyroid cancers.
Gene_expression (overexpressed) of Cyclo-oxygenase 2 in thyroid associated with thyroid neoplasm
1) Confidence 0.25 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.32 Pain Relevance 0.08
METHODS: The effects of diacerein, celecoxib, diclofenac, meloxicam and indomethacin on prostaglandin (PG) E2 production, cyclo-oxygenase-2 (COX-2) protein expression, nitrite levels, presence of MMP-1 and -13, and activation of nuclear factor-kappaB (NF-kappaB) were studied on stimulated OA synoviocytes and chondrocytes.
Gene_expression (expression) of cyclo-oxygenase-2 in chondrocytes
2) Confidence 0.08 Published 2008 Journal Rheumatology (Oxford) Section Body Doc Link 18375401 Disease Relevance 0.09 Pain Relevance 0
The attainment of the highest values of LH/hGC-R correlated, also on a time scale, with the triggering of cyclo-oxygenase-2 (COX-2) and placental growth factor (PlGF) production.
Gene_expression (production) of cyclo-oxygenase-2
3) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0 Pain Relevance 0
Resveratrol consumption was also associated with the reduced mammary expression of a number of proteins that are putatively involved in malignant progression, including cyclo-oxygenase-2, matrix metalloprotease-9 and nuclear factor-?
Gene_expression (expression) of cyclo-oxygenase-2 associated with malignant neoplastic disease
4) Confidence 0.01 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.80 Pain Relevance 0

General Comments

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