INT15096

Context Info Confidence 0.21 First Reported 1991 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 11 Total Number 11 Disease Relevance 7.14 Pain Relevance 2.43

transport (Pitpnm1) lipid particle (Pitpnm1) Golgi apparatus (Pitpnm1) endoplasmic reticulum (Pitpnm1) intracellular (Pitpnm1) cytoplasm (Pitpnm1)

Anatomy Link Frequency plasma 1 liver 1 SCh 1 VLG 1 IGL 1 Pitpnm1 (Mus musculus)

Pain Link Frequency Relevance Heat qutenza 33 99.98 cINOD 5 75.60 Inflammation 27 75.00 Quantitative sensory testing 32 67.64 unmyelinated 1 61.36 c fibre 2 51.44 fifth nerve 3 50.00 COX2 32 5.00 Pain 17 5.00 Pain threshold 4 5.00

Disease Link Frequency Relevance Heat Necrosis 114 99.92 Death 46 98.28 Hepatocellular Cancer 9 98.12 Pressure And Volume Under Development 5 97.56 Ganglion Cysts 9 97.40 Mycobacterial Infection 192 94.52 Toxicity 5 93.88 Vibrio Infection 3 90.24 Injury 10 86.96 Stress 2 84.84

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Because nimesulide, unlike the related nitroaromatic drug nilutamide, did not produce any detectable ROS during incubation with mouse hepatic microsomes, we conclude that mitochondrial uncoupling causes MPT and that ROS production is a secondary effect.

Positive_regulation (causes) of MPT

1) Confidence 0.21 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16140214 Disease Relevance 0.28 Pain Relevance 0

We found that isolated mouse liver mitochondria readily underwent Ca2+-dependent, cyclosporin A-sensitive MPT upon exposure to nimesulide (at >or=3 microM).

Positive_regulation (underwent) of MPT in liver

2) Confidence 0.14 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16140214 Disease Relevance 0.51 Pain Relevance 0.08

The present study indicates that 7 of 13 parameters (CDT, MPT, TSL, WDT, CPT, HPT and MDT) are necessary to examine sensory function after oral- and maxillofacial surgery.

Positive_regulation (necessary) of MPT

3) Confidence 0.02 Published 2010 Journal Head Face Med Section Body Doc Link PMC2984556 Disease Relevance 0.13 Pain Relevance 0.20

Irreversible induction of MPT leads to mitochondrial damage associated with mitochondrial swelling and subsequent necrosis of the cell.

Positive_regulation (induction) of MPT associated with necrosis and pressure and volume under development

4) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.60 Pain Relevance 0

A common mechanism of necrosis is induction of mitochondrial permeability transition (MPT), which is manifested as accelerated cell death with plasma membrane disintegration.

Positive_regulation (induction) of MPT in plasma associated with necrosis and death

5) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.47 Pain Relevance 0

In mitochondria incubated without albumin, nimesulide (50 microM) decreased the mitochondrial membrane potential (DeltaPsim), increased basal respiration, and potentiated the mitochondrial permeability transition (MPT) triggered by calcium preloading.

Positive_regulation (potentiated) of MPT

6) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16617166 Disease Relevance 0.74 Pain Relevance 0.11

In mitochondria incubated without albumin, nimesulide (50 microM) decreased the mitochondrial membrane potential (DeltaPsim), increased basal respiration, and potentiated the mitochondrial permeability transition (MPT) triggered by calcium preloading.

Positive_regulation (triggered) of MPT

7) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16617166 Disease Relevance 0.73 Pain Relevance 0.10

In conclusion, the weak acid, nimesulide, uncouples mitochondria and triggers MPT and ATP depletion in isolated mitochondria or hepatoma cells incubated without albumin.

Positive_regulation (triggers) of MPT associated with hepatocellular cancer

8) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16617166 Disease Relevance 0.56 Pain Relevance 0.04

Results suggest that capsaicin causes degeneration in the SCh, VLG, IGL, MPT, and OPT by selective destruction of a subpopulation of retinal ganglion cells with axonal projections to these sites.

Positive_regulation (causes) of MPT in SCh associated with ganglion cysts and qutenza

9) Confidence 0.00 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1714924 Disease Relevance 0.38 Pain Relevance 0.64

Results suggest that capsaicin causes degeneration in the SCh, VLG, IGL, MPT, and OPT by selective destruction of a subpopulation of retinal ganglion cells with axonal projections to these sites.

Positive_regulation (causes) of MPT in VLG associated with ganglion cysts and qutenza

10) Confidence 0.00 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1714924 Disease Relevance 0.38 Pain Relevance 0.64

Results suggest that capsaicin causes degeneration in the SCh, VLG, IGL, MPT, and OPT by selective destruction of a subpopulation of retinal ganglion cells with axonal projections to these sites.

Positive_regulation (causes) of MPT in IGL associated with ganglion cysts and qutenza

11) Confidence 0.00 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1714924 Disease Relevance 0.38 Pain Relevance 0.64

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