INT15096

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Context Info
Confidence 0.21
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.14
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Pitpnm1) lipid particle (Pitpnm1) Golgi apparatus (Pitpnm1)
endoplasmic reticulum (Pitpnm1) intracellular (Pitpnm1) cytoplasm (Pitpnm1)
Anatomy Link Frequency
plasma 1
liver 1
SCh 1
VLG 1
IGL 1
Pitpnm1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 33 99.98 Very High Very High Very High
cINOD 5 75.60 Quite High
Inflammation 27 75.00 Quite High
Quantitative sensory testing 32 67.64 Quite High
unmyelinated 1 61.36 Quite High
c fibre 2 51.44 Quite High
fifth nerve 3 50.00 Quite Low
COX2 32 5.00 Very Low Very Low Very Low
Pain 17 5.00 Very Low Very Low Very Low
Pain threshold 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 114 99.92 Very High Very High Very High
Death 46 98.28 Very High Very High Very High
Hepatocellular Cancer 9 98.12 Very High Very High Very High
Pressure And Volume Under Development 5 97.56 Very High Very High Very High
Ganglion Cysts 9 97.40 Very High Very High Very High
Mycobacterial Infection 192 94.52 High High
Toxicity 5 93.88 High High
Vibrio Infection 3 90.24 High High
Injury 10 86.96 High High
Stress 2 84.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because nimesulide, unlike the related nitroaromatic drug nilutamide, did not produce any detectable ROS during incubation with mouse hepatic microsomes, we conclude that mitochondrial uncoupling causes MPT and that ROS production is a secondary effect.
Positive_regulation (causes) of MPT
1) Confidence 0.21 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16140214 Disease Relevance 0.28 Pain Relevance 0
We found that isolated mouse liver mitochondria readily underwent Ca2+-dependent, cyclosporin A-sensitive MPT upon exposure to nimesulide (at >or=3 microM).
Positive_regulation (underwent) of MPT in liver
2) Confidence 0.14 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16140214 Disease Relevance 0.51 Pain Relevance 0.08
The present study indicates that 7 of 13 parameters (CDT, MPT, TSL, WDT, CPT, HPT and MDT) are necessary to examine sensory function after oral- and maxillofacial surgery.
Positive_regulation (necessary) of MPT
3) Confidence 0.02 Published 2010 Journal Head Face Med Section Body Doc Link PMC2984556 Disease Relevance 0.13 Pain Relevance 0.20
Irreversible induction of MPT leads to mitochondrial damage associated with mitochondrial swelling and subsequent necrosis of the cell.
Positive_regulation (induction) of MPT associated with necrosis and pressure and volume under development
4) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.60 Pain Relevance 0
A common mechanism of necrosis is induction of mitochondrial permeability transition (MPT), which is manifested as accelerated cell death with plasma membrane disintegration.
Positive_regulation (induction) of MPT in plasma associated with necrosis and death
5) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.47 Pain Relevance 0
In mitochondria incubated without albumin, nimesulide (50 microM) decreased the mitochondrial membrane potential (DeltaPsim), increased basal respiration, and potentiated the mitochondrial permeability transition (MPT) triggered by calcium preloading.
Positive_regulation (potentiated) of MPT
6) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16617166 Disease Relevance 0.74 Pain Relevance 0.11
In mitochondria incubated without albumin, nimesulide (50 microM) decreased the mitochondrial membrane potential (DeltaPsim), increased basal respiration, and potentiated the mitochondrial permeability transition (MPT) triggered by calcium preloading.
Positive_regulation (triggered) of MPT
7) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16617166 Disease Relevance 0.73 Pain Relevance 0.10
In conclusion, the weak acid, nimesulide, uncouples mitochondria and triggers MPT and ATP depletion in isolated mitochondria or hepatoma cells incubated without albumin.
Positive_regulation (triggers) of MPT associated with hepatocellular cancer
8) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16617166 Disease Relevance 0.56 Pain Relevance 0.04
Results suggest that capsaicin causes degeneration in the SCh, VLG, IGL, MPT, and OPT by selective destruction of a subpopulation of retinal ganglion cells with axonal projections to these sites.
Positive_regulation (causes) of MPT in SCh associated with ganglion cysts and qutenza
9) Confidence 0.00 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1714924 Disease Relevance 0.38 Pain Relevance 0.64
Results suggest that capsaicin causes degeneration in the SCh, VLG, IGL, MPT, and OPT by selective destruction of a subpopulation of retinal ganglion cells with axonal projections to these sites.
Positive_regulation (causes) of MPT in VLG associated with ganglion cysts and qutenza
10) Confidence 0.00 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1714924 Disease Relevance 0.38 Pain Relevance 0.64
Results suggest that capsaicin causes degeneration in the SCh, VLG, IGL, MPT, and OPT by selective destruction of a subpopulation of retinal ganglion cells with axonal projections to these sites.
Positive_regulation (causes) of MPT in IGL associated with ganglion cysts and qutenza
11) Confidence 0.00 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1714924 Disease Relevance 0.38 Pain Relevance 0.64

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