INT15096
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Because nimesulide, unlike the related nitroaromatic drug nilutamide, did not produce any detectable ROS during incubation with mouse hepatic microsomes, we conclude that mitochondrial uncoupling causes MPT and that ROS production is a secondary effect. | |||||||||||||||
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We found that isolated mouse liver mitochondria readily underwent Ca2+-dependent, cyclosporin A-sensitive MPT upon exposure to nimesulide (at >or=3 microM). | |||||||||||||||
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The present study indicates that 7 of 13 parameters (CDT, MPT, TSL, WDT, CPT, HPT and MDT) are necessary to examine sensory function after oral- and maxillofacial surgery. | |||||||||||||||
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Irreversible induction of MPT leads to mitochondrial damage associated with mitochondrial swelling and subsequent necrosis of the cell. | |||||||||||||||
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A common mechanism of necrosis is induction of mitochondrial permeability transition (MPT), which is manifested as accelerated cell death with plasma membrane disintegration. | |||||||||||||||
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In mitochondria incubated without albumin, nimesulide (50 microM) decreased the mitochondrial membrane potential (DeltaPsim), increased basal respiration, and potentiated the mitochondrial permeability transition (MPT) triggered by calcium preloading. | |||||||||||||||
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In mitochondria incubated without albumin, nimesulide (50 microM) decreased the mitochondrial membrane potential (DeltaPsim), increased basal respiration, and potentiated the mitochondrial permeability transition (MPT) triggered by calcium preloading. | |||||||||||||||
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In conclusion, the weak acid, nimesulide, uncouples mitochondria and triggers MPT and ATP depletion in isolated mitochondria or hepatoma cells incubated without albumin. | |||||||||||||||
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Results suggest that capsaicin causes degeneration in the SCh, VLG, IGL, MPT, and OPT by selective destruction of a subpopulation of retinal ganglion cells with axonal projections to these sites. | |||||||||||||||
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Results suggest that capsaicin causes degeneration in the SCh, VLG, IGL, MPT, and OPT by selective destruction of a subpopulation of retinal ganglion cells with axonal projections to these sites. | |||||||||||||||
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Results suggest that capsaicin causes degeneration in the SCh, VLG, IGL, MPT, and OPT by selective destruction of a subpopulation of retinal ganglion cells with axonal projections to these sites. | |||||||||||||||
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