INT150977

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.07
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
adipocytes 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 1 99.54 Very High Very High Very High
Endocannabinoid 35 98.88 Very High Very High Very High
Chronic pancreatitis 2 50.00 Quite Low
Angina 1 35.84 Quite Low
Cannabinoid receptor 7 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Neuropeptide y 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 171 99.58 Very High Very High Very High
Diabetes Mellitus 29 92.24 High High
Apnoea 31 74.64 Quite High
Insulin Resistance 4 74.08 Quite High
Impaired Glucose Tolerance 2 71.12 Quite High
Pancreatitis 2 50.00 Quite Low
Disorder Of Lipid Metabolism 8 41.80 Quite Low
Cv General 3 Under Development 1 35.84 Quite Low
Myocardial Infarction 1 35.16 Quite Low
Stroke 1 34.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, these results suggest that changes in serum leptin and insulin concentrations are independent on the etiology of chronic pancreatitis.


Neg (independent) Regulation (independent) of Regulation (changes) of serum leptin
1) Confidence 0.37 Published 2008 Journal Pancreas Section Body Doc Link 18376301 Disease Relevance 0 Pain Relevance 0
Obesity is the major factor regulating circulating leptin [24,25,45] which is also influenced by gender and age [23,46].
Regulation (influenced) of Regulation (regulating) of leptin associated with obesity
2) Confidence 0.27 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 0.97 Pain Relevance 0
The endocannabinoids, anandamide and 2-AG, are produced by adipocytes, where they stimulate lipogenesis via cannabinoid CB1 receptors and are under the negative control of leptin and insulin.
Regulation (under) of Regulation (control) of leptin in adipocytes associated with endocannabinoid, cannabinoid and obesity
3) Confidence 0.11 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2868848 Disease Relevance 1.10 Pain Relevance 0.23

General Comments

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