INT15099

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Context Info
Confidence 0.51
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 15
Disease Relevance 1.09
Pain Relevance 7.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 3
embryonic stages 1
neuron 1
inner nuclear layers 1
ganglion 1
Slc6a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 20 100.00 Very High Very High Very High
Somatostatin 16 100.00 Very High Very High Very High
Dynorphin 12 100.00 Very High Very High Very High
Neurotransmitter 248 99.52 Very High Very High Very High
Dorsal horn neuron 8 99.38 Very High Very High Very High
Spinal cord 386 98.92 Very High Very High Very High
midbrain 64 98.64 Very High Very High Very High
Neuropeptide 10 98.64 Very High Very High Very High
orphanin 8 97.76 Very High Very High Very High
substance P 12 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 80 99.68 Very High Very High Very High
Neuropathic Pain 18 96.84 Very High Very High Very High
Nociception 17 95.12 Very High Very High Very High
Pain 31 94.12 High High
Lung Cancer 8 84.32 Quite High
INFLAMMATION 11 73.44 Quite High
Hyperalgesia 7 70.64 Quite High
Targeted Disruption 16 64.60 Quite High
Inflammatory Pain 16 50.00 Quite Low
Catalepsy 2 40.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that at least part of the actions of NA-glycine were mediated by GLYT2 inhibition because GLYT2 is expressed at high levels within the spinal cord, and glycine receptor blockade produces allodynia in 'normal' animals and enhances nociceptive responses in pain pathways [28-30].
Gene_expression (expressed) of GLYT2 in spinal cord associated with nociception, pain, allodynia and spinal cord
1) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2042976 Disease Relevance 0.62 Pain Relevance 0.86
GlyT2 and VIAAT are initially expressed earlier than GlyT1 in the anterior spinal cord of the late neurula (stage 21).
Gene_expression (expressed) of GlyT2 in spinal cord associated with spinal cord
2) Confidence 0.18 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.52
Knockdown of Lhx1 and Lhx5 results in decreased expression of VIAAT, although they do not appear to be obligatory determinant of inhibitory neural phenotypes and appear to play no direct role in determining GlyT2 expression (Pillai et al., 2007).
Gene_expression (expression) of GlyT2 in neural
3) Confidence 0.15 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.14 Pain Relevance 0.08
The glycinergic neurotransmitter phenotype requires the expression of the transporters GlyT2 and VIAAT for proper neurotransmission (reviewed in Betz and Laube, 2006).
Gene_expression (expression) of GlyT2 associated with neurotransmitter
4) Confidence 0.15 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.24
Developing dorsal horn neurons in Ptf1a null embryos fail to express GlyT2 from E12.5 through E16.5 and Pax2?
Gene_expression (express) of GlyT2 in dorsal horn associated with dorsal horn neuron
5) Confidence 0.14 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.06 Pain Relevance 0.19
Other investigators have shown that GlyT1 and GlyT2 are expressed in the ganglion and inner nuclear layers of the frog (Rana pipiens) and rat retinas (Pena-Rangel et al., 2008).


Gene_expression (expressed) of GlyT2 in ganglion associated with ganglion cysts
6) Confidence 0.14 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.10 Pain Relevance 0.34
By stage 33 GlyT2 is found in the lateral forebrain, medial midbrain and mid-dorsal region of the spinal cord.
Gene_expression (found) of GlyT2 in spinal cord associated with midbrain and spinal cord
7) Confidence 0.12 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.06 Pain Relevance 0.49
Both GlyT2 and VIAAT must both be expressed for a cell to successfully perform as a glycinergic neuron.
Gene_expression (expressed) of GlyT2 in neuron
8) Confidence 0.12 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.09
Second, Pax2 is a downstream target of Ptf1a and controls subsets of transmitter phenotypes, including the expression of GlyT2, NPY, N/OFQ, DYN, and GAL, but is dispensable for SOM or ENK expression.
Gene_expression (expression) of GlyT2 associated with dynorphin, somatostatin and enkephalin
9) Confidence 0.09 Published 2008 Journal Dev. Biol. Section Abstract Doc Link 18634777 Disease Relevance 0 Pain Relevance 0.93
Third, for Lbx1, due to neuronal cell loss at late stages, our analyses focused on early embryonic stages, and we found that Lbx1 is required for the expression of GlyT2, NPY, N/OFQ and is partially responsible for SOM expression.
Gene_expression (expression) of GlyT2 in embryonic stages associated with somatostatin
10) Confidence 0.09 Published 2008 Journal Dev. Biol. Section Abstract Doc Link 18634777 Disease Relevance 0 Pain Relevance 0.87
First, Ptf1a appears to be a master regulator, as indicated by a requirement of Ptf1a for the expression of glycinergic marker GlyT2 and a set of peptides, including neuropeptide Y (NPY), nociceptin/orphanin FQ (N/OFQ), somatostatin (SOM), enkephalin (ENK), dynorphin (DYN) and galanin (GAL).
Gene_expression (expression) of GlyT2 associated with dynorphin, orphanin, somatostatin, neuropeptide and enkephalin
11) Confidence 0.09 Published 2008 Journal Dev. Biol. Section Abstract Doc Link 18634777 Disease Relevance 0 Pain Relevance 0.88
Second, Pax2 is a downstream target of Ptf1a and controls subsets of transmitter phenotypes, including the expression of GlyT2, NPY, N/OFQ, DYN, and GAL, but is dispensable for SOM or ENK expression.
Gene_expression (expression) of GlyT2 associated with dynorphin, somatostatin and enkephalin
12) Confidence 0.07 Published 2008 Journal Dev. Biol. Section Abstract Doc Link 18634777 Disease Relevance 0 Pain Relevance 0.94
Other investigators have shown that GlyT1 and GlyT2 are expressed in the ganglion and inner nuclear layers of the frog (Rana pipiens) and rat retinas (Pena-Rangel et al., 2008).


Gene_expression (expressed) of GlyT2 in inner nuclear layers associated with ganglion cysts
13) Confidence 0.05 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.10 Pain Relevance 0.34
A pseudopeptide analogue [pGlu6,Phe8 psi(CH2O)Gly9]SP6-11 (7) of SP related C-terminal hexapeptide [pGlu6]SP6-11 and two pseudopeptide analogues of [Leu5]enkephalinamide, [Tyr1 psi (CH2O)Gly2, Leu5] enkephalinamide (11) and [Gly2 psi (CH2O)-Gly3, Leu5]enkephalinamide (17), were synthesized.
Gene_expression (synthesized) of Gly2 associated with substance p
14) Confidence 0.01 Published 1991 Journal J. Med. Chem. Section Abstract Doc Link 1714957 Disease Relevance 0 Pain Relevance 0.40
A pseudopeptide analogue [pGlu6,Phe8 psi(CH2O)Gly9]SP6-11 (7) of SP related C-terminal hexapeptide [pGlu6]SP6-11 and two pseudopeptide analogues of [Leu5]enkephalinamide, [Tyr1 psi (CH2O)Gly2, Leu5] enkephalinamide (11) and [Gly2 psi (CH2O)-Gly3, Leu5]enkephalinamide (17), were synthesized.
Gene_expression (synthesized) of Gly2 associated with substance p
15) Confidence 0.01 Published 1991 Journal J. Med. Chem. Section Abstract Doc Link 1714957 Disease Relevance 0 Pain Relevance 0.40

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