INT1510

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Context Info
Confidence 0.48
First Reported 1978
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 94
Total Number 95
Disease Relevance 4.68
Pain Relevance 56.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
brain 3
enterocytes 3
nerve 3
retina 2
blood 2
PDYN (Homo sapiens)
PDYN - A2L (3)
Pain Link Frequency Relevance Heat
Enkephalin 411 100.00 Very High Very High Very High
Dynorphin 100 100.00 Very High Very High Very High
Opioid 88 100.00 Very High Very High Very High
narcan 44 100.00 Very High Very High Very High
agonist 28 100.00 Very High Very High Very High
opiate 27 100.00 Very High Very High Very High
antagonist 26 100.00 Very High Very High Very High
Serotonin 23 100.00 Very High Very High Very High
Neuropeptide 20 100.00 Very High Very High Very High
substance P 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pheochromocytoma 9 100.00 Very High Very High Very High
Nociception 2 100.00 Very High Very High Very High
Rheumatoid Arthritis 20 99.52 Very High Very High Very High
Mydriatic 4 99.48 Very High Very High Very High
Ganglion Cysts 4 99.08 Very High Very High Very High
Reprotox - General 1 1 98.98 Very High Very High Very High
Dyskinesias 2 98.88 Very High Very High Very High
Hemorrhage 1 98.76 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leu-enkephalin binding to cultured human T lymphocytes.
Leu-enkephalin Binding (binding) of in T lymphocytes associated with enkephalin
1) Confidence 0.48 Published 1984 Journal Cell Biol. Int. Rep. Section Title Doc Link 6325028 Disease Relevance 0 Pain Relevance 0.28
Leu-enkephalin binding to cultured human T lymphocytes.
Leu-enkephalin Binding (binding) of in T lymphocytes associated with enkephalin
2) Confidence 0.48 Published 1984 Journal Cell Biol. Int. Rep. Section Title Doc Link 6086152 Disease Relevance 0 Pain Relevance 0.28
Inhibition of binding of beta h-endorphin or Leu-enkephalin by beta h-endorphin analogs of various chain lengths in memmbrane preparations of the neuroblastoma x glioma NG108-15 cells has been investigated.
Leu-enkephalin Binding (binding) of in NG108-15 associated with neuroblastoma, enkephalin and glioma
3) Confidence 0.47 Published 1984 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 6099337 Disease Relevance 0.34 Pain Relevance 0.10
These linkage relationships establish that the secretory and transcriptional associations of ARVP and PDYN extend to a close physical relationship in the human genome.
PDYN Binding (associations) of
4) Confidence 0.47 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 1978246 Disease Relevance 0 Pain Relevance 0
Effect of differentiation on hydrolysis and association of Leu-enkephalin to K562(S) cells.
Leu-enkephalin Binding (association) of associated with enkephalin
5) Confidence 0.47 Published 1994 Journal Peptides Section Title Doc Link 7854972 Disease Relevance 0 Pain Relevance 0.29
The binding of tritiated Leu-enkephalin to phosphatidylserine and phosphatidylcholine vesicles, both unmodified and modified by the incorporation of free fatty acid, has been studied by steric exclusion chromatography, ultraviolet difference spectroscopy and fluorescence anisotropy.
Leu-enkephalin Binding (binding) of in vesicles associated with enkephalin
6) Confidence 0.47 Published 1986 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 3781738 Disease Relevance 0 Pain Relevance 0.24
Interaction of serotonin and leu-enkephalin on the habituating central neurons of Helix pomatia L. in situ and in vitro.
leu-enkephalin Binding (Interaction) of in neurons associated with enkephalin and serotonin
7) Confidence 0.47 Published 1989 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Title Doc Link 2565190 Disease Relevance 0 Pain Relevance 0.51
A direct chemical interaction between dynorphin and excitatory amino acids.
dynorphin Binding (interaction) of associated with dynorphin and excitatory amino acid
8) Confidence 0.47 Published 2001 Journal Neurochem. Res. Section Title Doc Link 11495350 Disease Relevance 0 Pain Relevance 0.90
We observed that both glutamate or aspartate bind non-covalently to dynorphin A and dynorphin 2-17.
dynorphin Binding (bind) of associated with glutamate and dynorphin
9) Confidence 0.47 Published 2001 Journal Neurochem. Res. Section Abstract Doc Link 11495350 Disease Relevance 0 Pain Relevance 0.93
We observed that both glutamate or aspartate bind non-covalently to dynorphin A and dynorphin 2-17.
dynorphin Binding (bind) of associated with glutamate and dynorphin
10) Confidence 0.47 Published 2001 Journal Neurochem. Res. Section Abstract Doc Link 11495350 Disease Relevance 0 Pain Relevance 0.93
D-Ala-D-Leu-enkephalin binding revealed a 26% decrease in the number but no change in the affinity of delta-opiate receptors in the striata of IDPN-treated rats.
D-Ala-D-Leu-enkephalin Binding (binding) of associated with opiate and enkephalin
11) Confidence 0.46 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3027623 Disease Relevance 0.45 Pain Relevance 0.27
Topography and associations of leu-enkephalin and luteinizing hormone-releasing hormone neuronal systems in the human diencephalon.
leu-enkephalin Binding (associations) of in diencephalon associated with enkephalin
12) Confidence 0.43 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 12679482 Disease Relevance 0.07 Pain Relevance 0.62
Interaction of Leu-enkephalin with isolated enterocytes from guinea pig: binding to specific receptors and stimulation of cAMP accumulation.
Leu-enkephalin Binding (Interaction) of in enterocytes associated with enkephalin
13) Confidence 0.43 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2982375 Disease Relevance 0 Pain Relevance 0.32
The specific binding of Leu-enkephalin and the stimulatory effect of the peptide on cAMP accumulation have been assessed in isolated enterocytes of guinea pig.
Leu-enkephalin Binding (binding) of in enterocytes associated with enkephalin
14) Confidence 0.43 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2982375 Disease Relevance 0 Pain Relevance 0.17
Interaction of Leu-enkephalin with isolated enterocytes from guinea pig: binding to specific receptors and stimulation of cAMP accumulation.
Leu-enkephalin Binding (binding) of in enterocytes associated with enkephalin
15) Confidence 0.43 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2982375 Disease Relevance 0 Pain Relevance 0.33
At both temperatures no specific binding of the proteolytic stable analogue 3H-D-Ala-D-Leu-enkephalin was found.
3H-D-Ala-D-Leu-enkephalin Neg (no) Binding (binding) of associated with enkephalin
16) Confidence 0.42 Published 1985 Journal Cell Biol. Int. Rep. Section Abstract Doc Link 2866037 Disease Relevance 0 Pain Relevance 0.79
The interaction of Leucine-enkephalin (Leu-enkephalin) with reactive nitrogen species has been investigated.
Leucine-enkephalin Binding (interaction) of associated with enkephalin
17) Confidence 0.41 Published 2006 Journal Free Radic. Res. Section Abstract Doc Link 16983996 Disease Relevance 0 Pain Relevance 0.65
The interaction of Leucine-enkephalin (Leu-enkephalin) with reactive nitrogen species has been investigated.
Leu-enkephalin Binding (interaction) of associated with enkephalin
18) Confidence 0.41 Published 2006 Journal Free Radic. Res. Section Abstract Doc Link 16983996 Disease Relevance 0 Pain Relevance 0.66
In the presence of proteolysis inhibitors, hydrolysis of Leu-enkephalin and association to cells of its radioactive label are reduced.
Leu-enkephalin Binding (association) of associated with enkephalin
19) Confidence 0.37 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8014025 Disease Relevance 0 Pain Relevance 0.44
We demonstrated the presence and the secretion in vivo and in vitro of immunoreactive preproenkephalin B-derived opioid peptides (alpha-neoendorphin, dynorphin and leumorphin) in human phaeochromocytomas.
alpha-neoendorphin Binding (presence) of associated with dynorphin and opioid
20) Confidence 0.37 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2882641 Disease Relevance 0 Pain Relevance 0.53

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