INT1510

Context Info Confidence 0.48 First Reported 1978 Last Reported 2010 Negated 4 Speculated 1 Reported most in Abstract Documents 94 Total Number 95 Disease Relevance 4.68 Pain Relevance 56.44

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)

Anatomy Link Frequency brain 3 enterocytes 3 nerve 3 retina 2 blood 2 PDYN (Homo sapiens) PDYN - A2L (3)

Pain Link Frequency Relevance Heat Enkephalin 411 100.00 Dynorphin 100 100.00 Opioid 88 100.00 narcan 44 100.00 agonist 28 100.00 opiate 27 100.00 antagonist 26 100.00 Serotonin 23 100.00 Neuropeptide 20 100.00 substance P 18 100.00

Disease Link Frequency Relevance Heat Pheochromocytoma 9 100.00 Nociception 2 100.00 Rheumatoid Arthritis 20 99.52 Mydriatic 4 99.48 Ganglion Cysts 4 99.08 Reprotox - General 1 1 98.98 Dyskinesias 2 98.88 Hemorrhage 1 98.76 Increased Venous Pressure Under Development 2 97.96 Attention Deficit Hyperactivity Disorder 1 97.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Leu-enkephalin binding to cultured human T lymphocytes.

Leu-enkephalin Binding (binding) of in T lymphocytes associated with enkephalin

1) Confidence 0.48 Published 1984 Journal Cell Biol. Int. Rep. Section Title Doc Link 6325028 Disease Relevance 0 Pain Relevance 0.28

Leu-enkephalin binding to cultured human T lymphocytes.

Leu-enkephalin Binding (binding) of in T lymphocytes associated with enkephalin

2) Confidence 0.48 Published 1984 Journal Cell Biol. Int. Rep. Section Title Doc Link 6086152 Disease Relevance 0 Pain Relevance 0.28

Inhibition of binding of beta h-endorphin or Leu-enkephalin by beta h-endorphin analogs of various chain lengths in memmbrane preparations of the neuroblastoma x glioma NG108-15 cells has been investigated.

Leu-enkephalin Binding (binding) of in NG108-15 associated with neuroblastoma, enkephalin and glioma

3) Confidence 0.47 Published 1984 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 6099337 Disease Relevance 0.34 Pain Relevance 0.10

These linkage relationships establish that the secretory and transcriptional associations of ARVP and PDYN extend to a close physical relationship in the human genome.

PDYN Binding (associations) of

4) Confidence 0.47 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 1978246 Disease Relevance 0 Pain Relevance 0

Effect of differentiation on hydrolysis and association of Leu-enkephalin to K562(S) cells.

Leu-enkephalin Binding (association) of associated with enkephalin

5) Confidence 0.47 Published 1994 Journal Peptides Section Title Doc Link 7854972 Disease Relevance 0 Pain Relevance 0.29

The binding of tritiated Leu-enkephalin to phosphatidylserine and phosphatidylcholine vesicles, both unmodified and modified by the incorporation of free fatty acid, has been studied by steric exclusion chromatography, ultraviolet difference spectroscopy and fluorescence anisotropy.

Leu-enkephalin Binding (binding) of in vesicles associated with enkephalin

6) Confidence 0.47 Published 1986 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 3781738 Disease Relevance 0 Pain Relevance 0.24

Interaction of serotonin and leu-enkephalin on the habituating central neurons of Helix pomatia L. in situ and in vitro.

leu-enkephalin Binding (Interaction) of in neurons associated with enkephalin and serotonin

7) Confidence 0.47 Published 1989 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Title Doc Link 2565190 Disease Relevance 0 Pain Relevance 0.51

A direct chemical interaction between dynorphin and excitatory amino acids.

dynorphin Binding (interaction) of associated with dynorphin and excitatory amino acid

8) Confidence 0.47 Published 2001 Journal Neurochem. Res. Section Title Doc Link 11495350 Disease Relevance 0 Pain Relevance 0.90

We observed that both glutamate or aspartate bind non-covalently to dynorphin A and dynorphin 2-17.

dynorphin Binding (bind) of associated with glutamate and dynorphin

9) Confidence 0.47 Published 2001 Journal Neurochem. Res. Section Abstract Doc Link 11495350 Disease Relevance 0 Pain Relevance 0.93

We observed that both glutamate or aspartate bind non-covalently to dynorphin A and dynorphin 2-17.

dynorphin Binding (bind) of associated with glutamate and dynorphin

10) Confidence 0.47 Published 2001 Journal Neurochem. Res. Section Abstract Doc Link 11495350 Disease Relevance 0 Pain Relevance 0.93

D-Ala-D-Leu-enkephalin binding revealed a 26% decrease in the number but no change in the affinity of delta-opiate receptors in the striata of IDPN-treated rats.

D-Ala-D-Leu-enkephalin Binding (binding) of associated with opiate and enkephalin

11) Confidence 0.46 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3027623 Disease Relevance 0.45 Pain Relevance 0.27

Topography and associations of leu-enkephalin and luteinizing hormone-releasing hormone neuronal systems in the human diencephalon.

leu-enkephalin Binding (associations) of in diencephalon associated with enkephalin

12) Confidence 0.43 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 12679482 Disease Relevance 0.07 Pain Relevance 0.62

Interaction of Leu-enkephalin with isolated enterocytes from guinea pig: binding to specific receptors and stimulation of cAMP accumulation.

Leu-enkephalin Binding (Interaction) of in enterocytes associated with enkephalin

13) Confidence 0.43 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2982375 Disease Relevance 0 Pain Relevance 0.32

The specific binding of Leu-enkephalin and the stimulatory effect of the peptide on cAMP accumulation have been assessed in isolated enterocytes of guinea pig.

Leu-enkephalin Binding (binding) of in enterocytes associated with enkephalin

14) Confidence 0.43 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2982375 Disease Relevance 0 Pain Relevance 0.17

Interaction of Leu-enkephalin with isolated enterocytes from guinea pig: binding to specific receptors and stimulation of cAMP accumulation.

Leu-enkephalin Binding (binding) of in enterocytes associated with enkephalin

15) Confidence 0.43 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2982375 Disease Relevance 0 Pain Relevance 0.33

At both temperatures no specific binding of the proteolytic stable analogue 3H-D-Ala-D-Leu-enkephalin was found.

3H-D-Ala-D-Leu-enkephalin Neg (no) Binding (binding) of associated with enkephalin

16) Confidence 0.42 Published 1985 Journal Cell Biol. Int. Rep. Section Abstract Doc Link 2866037 Disease Relevance 0 Pain Relevance 0.79

The interaction of Leucine-enkephalin (Leu-enkephalin) with reactive nitrogen species has been investigated.

Leucine-enkephalin Binding (interaction) of associated with enkephalin

17) Confidence 0.41 Published 2006 Journal Free Radic. Res. Section Abstract Doc Link 16983996 Disease Relevance 0 Pain Relevance 0.65

The interaction of Leucine-enkephalin (Leu-enkephalin) with reactive nitrogen species has been investigated.

Leu-enkephalin Binding (interaction) of associated with enkephalin

18) Confidence 0.41 Published 2006 Journal Free Radic. Res. Section Abstract Doc Link 16983996 Disease Relevance 0 Pain Relevance 0.66

In the presence of proteolysis inhibitors, hydrolysis of Leu-enkephalin and association to cells of its radioactive label are reduced.

Leu-enkephalin Binding (association) of associated with enkephalin

19) Confidence 0.37 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8014025 Disease Relevance 0 Pain Relevance 0.44

We demonstrated the presence and the secretion in vivo and in vitro of immunoreactive preproenkephalin B-derived opioid peptides (alpha-neoendorphin, dynorphin and leumorphin) in human phaeochromocytomas.

alpha-neoendorphin Binding (presence) of associated with dynorphin and opioid

20) Confidence 0.37 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2882641 Disease Relevance 0 Pain Relevance 0.53

General Comments

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