INT151018

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.48
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
neutrophil 3
blood 2
liver 2
leucocyte 1
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 6 95.28 Very High Very High Very High
Inflammation 48 94.92 High High
Inflammatory response 3 90.64 High High
ischemia 36 85.68 High High
cytokine 6 82.56 Quite High
Hippocampus 11 74.72 Quite High
qutenza 13 64.08 Quite High
Glutamate 3 31.20 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 30 100.00 Very High Very High Very High
Pleurisy 2 98.96 Very High Very High Very High
Middle Cerebral Artery Infarction 28 98.64 Very High Very High Very High
Diabetes Mellitus 33 98.32 Very High Very High Very High
INFLAMMATION 47 94.92 High High
Stress 15 89.52 High High
Peritonitis 4 88.00 High High
Cv Unclassified Under Development 22 85.68 High High
Adhesions 1 81.04 Quite High
Poisoning 1 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant (P < 0.01) increase in the activity of LDH in serum was observed in the ischemic (MCAO) group rats, as compared to the sham group; whereas, aqueous extract of Embelia ribes treatment significantly (P < 0.01) resulted in decreased serum LDH levels when compared with the ischemic (MCAO) group rats.
Negative_regulation (decreased) of Gene_expression (levels) of LDH associated with middle cerebral artery infarction
1) Confidence 0.32 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 0.54 Pain Relevance 0.04
RESULTS: Pretreatment with NTG (0.12 mg/kg i.v.) 24 h before ischemia-reperfusion (I/R) of super mesenteric artery significantly reduced histologic lesions and serum LDH with elevated blood levels of NO and CGRP.
Negative_regulation (reduced) of Gene_expression (lesions) of LDH in blood
2) Confidence 0.31 Published 2009 Journal J. Gastrointest. Surg. Section Body Doc Link 19002537 Disease Relevance 0 Pain Relevance 0
Pretreatment with aqueous and ethanolic extracts decreased the activities of alkaline phosphatase, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, and the level of bilirubin in the serum that were elevated by acetaminophen.
Negative_regulation (decreased) of Gene_expression (activities) of lactate dehydrogenase associated with paracetamol
3) Confidence 0.21 Published 2010 Journal Food Chem. Toxicol. Section Abstract Doc Link 20553784 Disease Relevance 0.23 Pain Relevance 0.45
mg/kg doses of F2, resp.) showed significant decrease (P < .001) in ISO-affected levels of CK-MB, LDH, GOT, ALK-P, and uric acid in a dose-dependent manner compared to Group II (vehicle-treated group injected with ISO), while Group VI (administered with 50?
Negative_regulation (decrease) of Gene_expression (levels) of LDH
4) Confidence 0.17 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952329 Disease Relevance 0.14 Pain Relevance 0
In this study, it is shown that in group 3, ALT, AST, and LDH enzymes, markers of liver parenchymal injury, have decreased levels in comparison with group 2 (p<0.0001).
Negative_regulation (decreased) of Gene_expression (enzymes) of LDH in liver associated with injury
5) Confidence 0.14 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 1.37 Pain Relevance 0.30
The activities of different key enzymes (hexokinase, glucose-6-phosphate dehydrogenase and lactate dehydrogenase) are represented in Figs 1, 2 and 3.
Negative_regulation (represented) of Gene_expression (dehydrogenase) of lactate dehydrogenase
6) Confidence 0.13 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193540 Disease Relevance 0.23 Pain Relevance 0
Pretreatment (30 min) of rats with pepper juice (0.25-2.0 g kg(-1)) significantly decreased leucocyte and neutrophil migration, exudate volume and protein and LDH concentration in pleural exudates of a pleurisy model.
Negative_regulation (decreased) of Gene_expression (concentration) of LDH in neutrophil associated with pleurisy
7) Confidence 0.07 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18380920 Disease Relevance 1.48 Pain Relevance 0.63
Pretreatment (30 min) of rats with pepper juice (0.25-2.0 g kg(-1)) significantly decreased leucocyte and neutrophil migration, exudate volume and protein and LDH concentration in pleural exudates of a pleurisy model.
Negative_regulation (decreased) of in leucocyte Gene_expression (concentration) of LDH in neutrophil associated with pleurisy
8) Confidence 0.03 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18380920 Disease Relevance 1.48 Pain Relevance 0.63

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