INT151029

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 4.04
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) transport (Lcn2) extracellular space (Lcn2)
extracellular region (Lcn2)
Anatomy Link Frequency
chondrocytes 4
Nasal 4
colon 2
respiratory tract 2
intestine 2
Lcn2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 100.00 Very High Very High Very High
dexamethasone 50 99.98 Very High Very High Very High
cINOD 5 97.72 Very High Very High Very High
Inflammation 106 97.22 Very High Very High Very High
antagonist 5 96.04 Very High Very High Very High
chemokine 51 74.84 Quite High
cytokine 6 56.40 Quite High
wide dynamic range 1 45.80 Quite Low
Inflammatory response 37 44.40 Quite Low
anesthesia 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 64 100.00 Very High Very High Very High
Colon Cancer 1 100.00 Very High Very High Very High
Salmonella Infection 12 99.98 Very High Very High Very High
Pancreatic Cancer 59 99.84 Very High Very High Very High
Bacterial Meningitis 6 99.76 Very High Very High Very High
Cancer 171 99.44 Very High Very High Very High
INFLAMMATION 148 97.52 Very High Very High Very High
Infection 48 90.52 High High
Adhesions 5 90.08 High High
Ovarian Cancer 1 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The respiratory tract secretes Lcn2 at basal levels and rapidly upregulates Lcn2 expression during colonization [4],[6].
Positive_regulation (upregulates) of Gene_expression (expression) of Lcn2 in respiratory tract
1) Confidence 0.68 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.21 Pain Relevance 0.04
Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.
Positive_regulation (induced) of Gene_expression (expression) of lipocalin 2 in chondrocytes associated with dexamethasone
2) Confidence 0.63 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 18381927 Disease Relevance 0.10 Pain Relevance 0.40
This synergistic effect may be explained by a further increase in lipocalin 2 expression with Dex treatment of transfected cells (45%, P < 0.05).
Positive_regulation (increase) of Gene_expression (expression) of lipocalin 2 associated with dexamethasone
3) Confidence 0.63 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0 Pain Relevance 0.41
However, Salmonella infection induces Lcn2 production in the intestine, and the ability to utilize Gly-Ent confers a competitive advantage over an iroN mutant during intestinal inflammation [31].
Positive_regulation (induces) of Gene_expression (production) of Lcn2 in intestine associated with salmonella infection and inflammation
4) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.25 Pain Relevance 0.05
Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

Nasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2).

Positive_regulation (induces) of Gene_expression (expression) of lipocalin 2 in Nasal associated with inflammation
5) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Title Doc Link PMC2757716 Disease Relevance 0.32 Pain Relevance 0.12
Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

Nasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2).

Positive_regulation (induces) of Gene_expression (expression) of Lcn2 in Nasal associated with inflammation
6) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Title Doc Link PMC2757716 Disease Relevance 0.32 Pain Relevance 0.12
In mice, the nasal mucosa responds to Streptococcus pneumoniae colonization by increasing Lcn2 mRNA expression (65-fold) [6].
Positive_regulation (n by incre) of Gene_expression (mRNA expre) of Lcn2 in nasal mucosa associated with bacterial meningitis
7) Confidence 0.46 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.60 Pain Relevance 0
The effects of lipocalin 2 overexpression on chondrocyte proliferation (64%, P < 0.05) and collagen type X expression (8-fold, P < 0.05) were further exacerbated with the addition of 10(-6) M Dex.
Positive_regulation (overexpression) of Gene_expression (overexpression) of lipocalin 2 in chondrocyte associated with dexamethasone
8) Confidence 0.46 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0 Pain Relevance 0.42
Enterobactin-producing K. pneumoniae elicit a lipocalin 2-dependent increase in neutrophil influx
Positive_regulation (increase) of Gene_expression (producing) of lipocalin 2-dependent in neutrophil
9) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.07
Lipocalin 2 expression increased 40-fold after 24-h Dex treatment.
Positive_regulation (increased) of Gene_expression (expression) of Lipocalin 2 associated with dexamethasone
10) Confidence 0.43 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0.08 Pain Relevance 0.42
Proliferation in lipocalin 2-overexpressing cells was less than in control cells (49%, P < 0.05), and overexpression caused an increase in collagen type X expression (4-fold, P < 0.05).
Positive_regulation (2-overexpressing) of Gene_expression (overexpressing) of lipocalin 2
11) Confidence 0.40 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0.06 Pain Relevance 0.48
LCN2 has been shown to play a role in regulating cellular growth and metastasis in colon cancer [45] and to be overexpressed in pancreatic cancer at the mRNA levels [46], concordant with gene expression analysis of tumors from our mouse model (Table 1).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LCN2 in colon associated with cancer, pancreatic cancer, colon cancer and metastasis
12) Confidence 0.34 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.47 Pain Relevance 0
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Positive_regulation (elevated) of Gene_expression (expression) of Lcn2 in extracellular matrix associated with metalloproteinase
13) Confidence 0.28 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.43 Pain Relevance 0.12

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