INT151033

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.06
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col10a1) proteinaceous extracellular matrix (Col10a1)
Anatomy Link Frequency
chondrocyte 2
Col10a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 94.92 High High
antagonist 1 91.64 High High
dexamethasone 10 86.92 High High
cINOD 1 52.48 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 5 99.72 Very High Very High Very High
Osteoarthritis 96 94.92 High High
INFLAMMATION 1 52.24 Quite High
Spinal Osteophytosis 1 50.80 Quite High
Disease 12 42.52 Quite Low
Aging 13 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Arthropathy 2 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proliferation in lipocalin 2-overexpressing cells was less than in control cells (49%, P < 0.05), and overexpression caused an increase in collagen type X expression (4-fold, P < 0.05).
Positive_regulation (increase) of Gene_expression (expression) of collagen type X
1) Confidence 0.26 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0.05 Pain Relevance 0.48
Chondrocytes present in the articular cartilage of Smad3-deficient mice showed enhanced chondrocyte hypertrophy indicated by increased expression of type X collagen.
Positive_regulation (increased) of Gene_expression (expression) of type X collagen in chondrocyte associated with hypertrophy
2) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 1.01 Pain Relevance 0.38

General Comments

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