INT151036

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.57
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) transport (Lcn2) extracellular space (Lcn2)
extracellular region (Lcn2)
Anatomy Link Frequency
connective 1
neutrophil 1
Lcn2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 5 100.00 Very High Very High Very High
Inflammation 164 99.56 Very High Very High Very High
dexamethasone 20 97.76 Very High Very High Very High
Inflammatory response 42 93.28 High High
agonist 31 92.88 High High
cINOD 6 83.00 Quite High
chemokine 48 77.36 Quite High
wide dynamic range 3 65.80 Quite High
Inflammatory mediators 3 23.36 Low Low
cytokine 25 8.08 Low Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 3 100.00 Very High Very High Very High
Hemophilus Infection 5 99.84 Very High Very High Very High
INFLAMMATION 204 99.56 Very High Very High Very High
Sprains And Strains 134 99.34 Very High Very High Very High
Pancreatic Cancer 177 98.80 Very High Very High Very High
Pneumonia 60 98.76 Very High Very High Very High
Cancer 456 98.44 Very High Very High Very High
Adhesions 9 95.52 Very High Very High Very High
Pancreatitis 36 91.60 High High
Bacterial Meningitis 5 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesize that as bacterial density increases Lcn2 becomes a pro-inflammatory signal.
Positive_regulation (increases) of Lcn2 associated with inflammation
1) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.22 Pain Relevance 0.21
Whether Ent production stimulates Lcn2-dependent inflammation during pneumonia remains to be determined.
Positive_regulation (stimulates) of Lcn2 associated with inflammation and pneumonia
2) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.82 Pain Relevance 0.13
As a countermeasure, pathogens of the Enterobacteriaceae family such as Klebsiella pneumoniae produce additional siderophores such as yersiniabactin (Ybt) and contain the iroA locus encoding an Ent glycosylase that prevents Lcn2 binding.
Positive_regulation (prevents) of Lcn2
3) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.33 Pain Relevance 0.12
Cancer persisted at 16 weeks only in the A/J strain and contained a large number of upregulated genes such as C13ORF15, LRG1, LCN2, MMP12 and SAA2 (Table 4).
Positive_regulation (upregulated) of LCN2 associated with cancer and sprains and strains
4) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.50 Pain Relevance 0.12
Lcn2 is also induced by Haemophilus influenzae colonization, suggesting its production is a general response to colonizing bacteria [6].
Positive_regulation (induced) of Lcn2 associated with hemophilus infection
5) Confidence 0.46 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.56 Pain Relevance 0
The lipocalin 2 response was blocked by the GC-receptor antagonist RU-486 and was increased further by the protein synthesis blocker cycloheximide.
Positive_regulation (increased) of lipocalin 2 associated with antagonist
6) Confidence 0.46 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0.06 Pain Relevance 0.47
Enterobactin-producing K. pneumoniae elicit a lipocalin 2-dependent increase in neutrophil influx
Positive_regulation (increase) of lipocalin 2-dependent in neutrophil
7) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.07
Downregulated genes included secreted frizzled-related protein and IGF-I, and upregulated genes included serum/GC-regulated kinase, connective-tissue growth factor, and lipocalin 2.
Positive_regulation (upregulated) of lipocalin 2 in connective
8) Confidence 0.43 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18381927 Disease Relevance 0.08 Pain Relevance 0.42
From the list of nine candidate markers found elevated by proteomics and validated in human samples, only LCN2 was not significantly elevated.
Neg (not) Positive_regulation (elevated) of LCN2
9) Confidence 0.34 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 0.97 Pain Relevance 0
Elevated levels of ALCAM, IGFBP4, LCN2, and WFDC2 in circulation in pancreatic cancer are novel findings.
Positive_regulation (levels) of LCN2 associated with pancreatic cancer
10) Confidence 0.34 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.18 Pain Relevance 0.06
Elevated levels of ALCAM, IGFBP4, LCN2, and WFDC2 in circulation in pancreatic cancer are novel findings.
Positive_regulation (Elevated) of LCN2 associated with pancreatic cancer
11) Confidence 0.34 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.18 Pain Relevance 0.06
This comprises induction of mucins, lipocalin-2, RegIII?
Positive_regulation (induction) of lipocalin-2
12) Confidence 0.06 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.03 Pain Relevance 0.16
include a number of acute phase genes such as fibrinogen, serum amyloid P-component, lipocalin 2, metallothioneins, and serum amyloid A2, which were shown to be suppressed by the PPAR?
Positive_regulation (serum) of lipocalin 2 associated with alzheimer's dementia
13) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.42 Pain Relevance 0.17

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