INT151039

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.01
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Il23r)
Anatomy Link Frequency
T cells 1
Il23r (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 52 99.76 Very High Very High Very High
spinal inflammation 23 99.40 Very High Very High Very High
cytokine 50 96.84 Very High Very High Very High
cINOD 1 94.12 High High
rheumatoid arthritis 98 93.12 High High
spondylitis 1 91.92 High High
psoriasis 5 90.00 High High
Inflammation 31 75.44 Quite High
methotrexate 9 13.20 Low Low
Arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 77 99.76 Very High Very High Very High
Low Back Pain 24 99.40 Very High Very High Very High
Inflammatory Bowel Disease 54 99.36 Very High Very High Very High
INFLAMMATION 29 93.88 High High
Rheumatoid Arthritis 98 93.12 High High
Psoriasis 5 90.00 High High
Ileal Diseases 5 89.88 High High
Genetic Predisposition To Disease 1 85.72 High High
Cancer 4 50.00 Quite Low
Necrosis 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: This concurrent analysis of 3 distinct AS populations and their regional controls demonstrates a disease association with the IL-23R locus and implicates the same polymorphisms associated with IBD and psoriasis.


IL-23R Binding (association) of
1) Confidence 0.42 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18383363 Disease Relevance 0 Pain Relevance 0
Association of interleukin-23 receptor variants with ankylosing spondylitis.
interleukin-23 receptor Binding (Association) of associated with spinal inflammation
2) Confidence 0.32 Published 2008 Journal Arthritis Rheum. Section Title Doc Link 18383363 Disease Relevance 0.54 Pain Relevance 0.44
We conducted an extended analysis in the UK population and a meta-analysis with the previously published studies, in order to refine these IL-23R associations with AS.
IL-23R Binding (associations) of
3) Confidence 0.26 Published 2009 Journal Rheumatology (Oxford) Section Abstract Doc Link 19189980 Disease Relevance 0.07 Pain Relevance 0.07
OBJECTIVES: It has been shown previously that IL-23R variants are associated with AS.
IL-23R Binding (associated) of
4) Confidence 0.23 Published 2009 Journal Rheumatology (Oxford) Section Abstract Doc Link 19189980 Disease Relevance 0.07 Pain Relevance 0.07
Given that SNPs within CCR6, STAT3, JAK2, IL23R, IL12B, the IL22/IL26 and the IL2/IL21 gene cluster have been found to be associated with CD and or UC, we should take in mind the influence of these SNPs on Th17 cytokine profiles.
IL23R Binding (associated) of associated with inflammatory bowel disease, crohn's disease and cytokine
5) Confidence 0.22 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.51 Pain Relevance 0.29
RESULTS: No IL-23R SNP were found to be associated with AS in Koreans.
IL-23R SNP Binding (associated) of
6) Confidence 0.19 Published 2009 Journal J. Rheumatol. Section Body Doc Link 19369463 Disease Relevance 0.17 Pain Relevance 0
Recent studies including linkage analyses as well as candidate gene and, most recently, genome-wide association studies indicate significant associations of the interleukin-1 gene cluster, interleukin-23 receptor and ARTS1 genes as well as other possible loci with AS.
interleukin-23 receptor Binding (associations) of associated with spinal inflammation
7) Confidence 0.11 Published 2009 Journal Joint Bone Spine Section Abstract Doc Link 19541528 Disease Relevance 0.88 Pain Relevance 0.64
In contrast to the IL-22-positive CD4 T cells, the frequency of IL-23R-positive CD4 T cells did not correlate with IL-17-producing CD4 T cells in either PBMC or SFMC compartments, nor was there any correlation with disease activity.


IL-23R-positive Neg (not) Binding (correlate) of in T cells associated with disease
8) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.76 Pain Relevance 0.33

General Comments

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