INT15109

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Context Info
Confidence 0.65
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.21
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (H6PD) endoplasmic reticulum (H6PD) carbohydrate metabolic process (H6PD)
H6PD (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 246 98.80 Very High Very High Very High
nud 1 94.44 High High
Osteoarthritis 1 66.96 Quite High
Pain 1 65.68 Quite High
Inflammation 2 50.48 Quite High
cva 7 46.00 Quite Low
backache 1 39.60 Quite Low
cytokine 1 25.00 Low Low
corticosteroid 18 5.00 Very Low Very Low Very Low
local anesthetic 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 1 100.00 Very High Very High Very High
Septic Abortion 1 99.92 Very High Very High Very High
Hemolytic Anemia 1 99.70 Very High Very High Very High
Malaria 1 99.24 Very High Very High Very High
Hemolysis 7 98.96 Very High Very High Very High
Impaired Glucose Tolerance 258 98.80 Very High Very High Very High
Disease 3 98.52 Very High Very High Very High
Hypophosphatemia 1 98.00 Very High Very High Very High
Pressure And Volume Under Development 3 96.02 Very High Very High Very High
Hepatocellular Cancer 2 95.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excluding patients in circulatory shock and/or hepatic coma, acute pancreatitis as defined by an elevation of serum amylase and clinical signs (epigastric pain) was present in four, with additional ultrasound findings (pancreatic swelling) and/or laparatomy/postmortem findings in a further six subjects (total ten patients = 25%) with various causes of hemolysis: autoimmune hemolysis 2, microangiopathic hemolytic anemia 2, toxicemia, G-6-PDH deficiency, septic abortion, malaria, Wilson's disease, and hypophosphatemia, one case each.
Gene_expression (deficiency) of G-6-PDH associated with septic abortion, pressure and volume under development, hemolytic anemia, pancreatitis, shock, nud, disease, malaria, hypophosphatemia, hepatic encephalopathy and hemolysis
1) Confidence 0.65 Published 1991 Journal Ann. Hematol. Section Abstract Doc Link 1715192 Disease Relevance 2.14 Pain Relevance 0.07
Furthermore, the therapy increased the levels of alpha atrial natriuretic polypeptide (alpha ANP), beta endorphin, adrenocorticotropic hormone (ACTH), insulin and glucose-6-phosphate dehydrogenase (G-6-PDH), and it decreased the vasopression level.
Gene_expression (levels) of G-6-PDH associated with natriuresis
2) Confidence 0.58 Published 2004 Journal J. Radiat. Res. Section Abstract Doc Link 15133294 Disease Relevance 0.33 Pain Relevance 0.10
Actually, recent findings showed that human hepatoma HepG2 cells which were treated with H2O2 accumulated triglycerides through up-regulation of genes encoding SREBP-1c and other genes involved in fatty acid metabolism [8], and experiments from our research group revealed a higher mRNA expression of fatty acid synthase (FAS), glucose-6-phosphate dehydrogenase (G6PDH) and stearoyl-CoA desaturase (SCD)-1 in HepG2 cells treated with pro-oxidant CuSO4 compared to untreated cells [9].
Gene_expression (expression) of G6PDH associated with hepatocellular cancer
3) Confidence 0.09 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2881051 Disease Relevance 0.75 Pain Relevance 0
Sexually dimorphic expression of H6PDH has not been described previously, and the observed increase in expression in men will need to be endorsed with dedicated activity studies to see if changes in H6PDH expression translate into alterations in glucocorticoid availability.
Gene_expression (expression) of H6PDH
4) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.26 Pain Relevance 0.03
Sexually dimorphic expression of H6PDH has not been described previously, and the observed increase in expression in men will need to be endorsed with dedicated activity studies to see if changes in H6PDH expression translate into alterations in glucocorticoid availability.
Gene_expression (expression) of H6PDH
5) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.32 Pain Relevance 0.03
Decreases in H6PDH expression and activity decrease oxoreductase and increase dehydrogenase activity (12,13).
Gene_expression (expression) of H6PDH
6) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.98 Pain Relevance 0.09
H6PDH expression was lower in female volunteers with IGT (0.79 ± 0.1 vs. 1.38 ± 0.14 AU, P < 0.05), but GR and 5?
Gene_expression (expression) of H6PDH associated with tolerance
7) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.76 Pain Relevance 0.20
R1 mRNA expression levels were similar in men and women, H6PDH expression was higher in biopsies from male volunteers (2.3 ± 0.4 vs. 1.6 ± 0.5 AU, P < 0.05).
Gene_expression (expression) of H6PDH
8) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.83 Pain Relevance 0.28
However, due to the small volumes of tissue obtained, activity studies were not performed and it is possible that decreased H6PDH expression that we also observed in the IGT group may decrease 11?
Gene_expression (expression) of H6PDH associated with tolerance
9) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.84 Pain Relevance 0.12

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