INT151097

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L10) mitochondrion (BCL2L10) nucleus (BCL2L10)
Anatomy Link Frequency
bladder 2
BCL2L10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
nociceptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 6 100.00 Very High Very High Very High
Cancer 14 97.06 Very High Very High Very High
Hepatocellular Cancer 36 94.08 High High
Overactive Bladder 13 91.04 High High
Hypertrophy 1 84.40 Quite High
Hyperplasia 1 83.36 Quite High
Lower Urinary Tract Symptoms 26 80.68 Quite High
Liver Cancer 2 57.16 Quite High
Hepatitis 2 18.40 Low Low
Cirrhosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypothetical explanations for BOO induced bladder dysfunction have been illustrated in animal and human models (26-28).
Positive_regulation (induced) of BOO in bladder
1) Confidence 0.44 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811296 Disease Relevance 0.78 Pain Relevance 0
TRPA1 mRNA in the bladder mucosa with BOO was significantly upregulated to 2.32 times of control.
Positive_regulation (upregulated) of BOO in bladder
2) Confidence 0.32 Published 2008 Journal Urology Section Body Doc Link 18384850 Disease Relevance 0 Pain Relevance 0
It has also been observed that the tumor-suppressor PTEN, the Akt/PKB pathway inhibitor [17], was down-regulated drastically, leading to an increased activity of Akt/PKB, as shown by the anti-apoptotic protein Bcl-2 and the cell-cycle inhibitor p27kip, which were induced and inhibited, respectively.
Positive_regulation (induced) of anti-apoptotic protein Bcl-2 associated with cancer and apoptosis
3) Confidence 0.07 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.65 Pain Relevance 0

General Comments

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