INT151098

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR)
enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)
CFTR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 21 97.88 Very High Very High Very High
bradykinin 10 94.00 High High
sodium channel 9 88.64 High High
cINOD 4 76.88 Quite High
fibrosis 11 76.00 Quite High
Inflammation 34 68.64 Quite High
Inflammatory mediators 20 44.64 Quite Low
adenocard 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 11 76.00 Quite High
INFLAMMATION 59 75.44 Quite High
Pyelonephritis 4 73.36 Quite High
Renal Disease 1 69.20 Quite High
Natriuresis 2 21.96 Low Low
Heart Rate Under Development 11 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Diarrhoea 8 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of ibuprofen to the extracellular solution caused a rapid inhibition of CFTR activity in IB3-8-3-7 cells in the presence of a high intracellular concentration of cAMP, whereas ibuprofen enhanced the CFTR conductance at low levels of cAMP.
Positive_regulation (enhanced) of Positive_regulation (conductance) of CFTR
1) Confidence 0.50 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.58 Pain Relevance 0.40
TGF beta1 was found to lead to perinuclear accumulation of CFTR protein and reduced chloride secretory responses to cAMP stimulating agents [82].
Positive_regulation (lead) of Positive_regulation (accumulation) of CFTR protein
2) Confidence 0.27 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.33 Pain Relevance 0.23

General Comments

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