INT151099

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 10.28
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR)
enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)
Anatomy Link Frequency
epithelial cells 4
lungs 2
HT-29 1
T84 1
CFTR (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 646 100.00 Very High Very High Very High
Inflammation 225 98.24 Very High Very High Very High
cINOD 17 96.00 Very High Very High Very High
cytokine 136 85.84 High High
Inflammatory mediators 120 53.76 Quite High
Inflammatory response 19 36.64 Quite Low
chemokine 12 34.72 Quite Low
bradykinin 60 22.68 Low Low
substance P 18 9.92 Low Low
adenocard 30 8.76 Low Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 646 100.00 Very High Very High Very High
Bone Cancer 125 98.60 Very High Very High Very High
INFLAMMATION 369 98.24 Very High Very High Very High
Exocrine Pancreatic Insufficiency 25 98.20 Very High Very High Very High
Bronchiectasis 6 98.12 Very High Very High Very High
Pulmonary Disease 41 97.04 Very High Very High Very High
Infection 39 97.04 Very High Very High Very High
Pseudomonas Infection 6 96.44 Very High Very High Very High
Colitis 18 95.68 Very High Very High Very High
Heart Rate Under Development 70 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paradoxically, ibuprofen inhibits ligand-stimulated CF transmembrance conductance regulator (CFTR) activity.
Negative_regulation (inhibits) of CFTR associated with fibrosis
1) Confidence 0.59 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.55 Pain Relevance 0.36
Addition of ibuprofen to the extracellular solution caused a rapid inhibition of CFTR activity in IB3-8-3-7 cells in the presence of a high intracellular concentration of cAMP, whereas ibuprofen enhanced the CFTR conductance at low levels of cAMP.
Negative_regulation (inhibition) of CFTR
2) Confidence 0.59 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.58 Pain Relevance 0.40
Paradoxically, ibuprofen inhibits ligand-stimulated CF transmembrance conductance regulator (CFTR) activity.
Negative_regulation (inhibits) of CF transmembrance conductance regulator associated with fibrosis
3) Confidence 0.59 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.55 Pain Relevance 0.36
Antagonistic effects may have IFN gamma because short-circuit current measurements in the Ussing chamber of bronchial epithelial cells showed that it decreases CFTR dependent chloride secretion significantly, which was associated with a reduction in CFTR mRNA [49].
Negative_regulation (reduction) of CFTR mRNA in epithelial cells
4) Confidence 0.34 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.41 Pain Relevance 0.15
There is evidence that in alveolar epithelial cells as opposed to upper airways epithelia a reduction in CFTR function is linked to a reduction in sodium transport through ENaC, which may contribute to the reduced lung liquid clearance observed in pulmonary edema.
Negative_regulation (reduction) of CFTR in lung associated with heart rate under development
5) Confidence 0.34 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.36 Pain Relevance 0.03
Other studies have demonstrated a NO induced reduction in chloride secretion, which appears to be related to an inhibition of cAMP dependent CFTR trafficking inside intestinal epithelial cells [84].
Negative_regulation (inhibition) of CFTR in epithelial cells
6) Confidence 0.30 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.10 Pain Relevance 0.07
Experiments with the gut derived epithelial cell lines T84 and HT-29 showed that interferon gamma and TNF both independently and if applied together synergistically, reduce CFTR mRNA by destabilization of transcripts and with prolonged [> 24 hour] exposure also CFTR protein on the cell surface.
Negative_regulation (reduce) of CFTR mRNA in HT-29
7) Confidence 0.25 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.05 Pain Relevance 0.07
Expression of epithelial inducible nitric oxide synthase and NO production was reduced in a human trachea epithelial cell line where CFTR activity was blocked by the over-expression of the CFTR regulatory domain.
Negative_regulation (blocked) of CFTR in epithelial cell
8) Confidence 0.25 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.43 Pain Relevance 0.21
kb YAC [21], express CFTR in an appropriate tissue specific manner and complement the cftr defect in null mice.
Negative_regulation (defect) of cftr
9) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.47 Pain Relevance 0.05
In addition, the loss or reduction in CFTR activity has been shown to lead to chronic inflammation through a decrease in osteoprotegerin and a concomitant increase in prostaglandin E2 [2].
Negative_regulation (reduction) of CFTR associated with inflammation
10) Confidence 0.22 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 1.38 Pain Relevance 0.41
The defects in CFTR leads to alterations in the sodium, chloride, and water transport in the epithelial cells and in turn to changes in the viscosity and hydration of the fluids overlying the epithelial cells.
Negative_regulation (defects) of CFTR in epithelial cells
11) Confidence 0.22 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.92 Pain Relevance 0.25
In addition, the loss or reduction in CFTR activity has been shown to lead to chronic inflammation through a decrease in osteoprotegerin and a concomitant increase in prostaglandin E2 [2].
Negative_regulation (loss) of CFTR associated with inflammation
12) Confidence 0.22 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 1.38 Pain Relevance 0.41
Cystic fibrosis (CF) is an autosomal recessive disorder caused by defects in the cystic fibrosis transmembrane conductance regulator protein (CFTR), a chloride channel found in the epithelial tissues in the lungs, sinuses, pancreas, skin, and gastrointestinal tract.
Negative_regulation (defects) of CFTR in lungs associated with fibrosis and cystic fibrosis
13) Confidence 0.22 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.68 Pain Relevance 0.27
Together these findings suggest that loss of CFTR function may adversely affect bone density.
Negative_regulation (loss) of CFTR
14) Confidence 0.22 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 1.39 Pain Relevance 0.41
Cystic fibrosis (CF) is the most common life-limiting autosomal recessive disorder in the Caucasian population with approximately 7000 affected individuals in the UK.1 A mutation in the CF gene leads to a defective or absent CF transmembrane conductance regulator (CFTR) which, in most patients, ultimately leads to bronchiectasis and chronic infection with Pseudomonas aeruginosa.
Negative_regulation (defective) of CFTR associated with fibrosis, pseudomonas infection, bronchiectasis, cystic fibrosis and infection
15) Confidence 0.12 Published 2010 Journal Thorax Section Body Doc Link PMC2921289 Disease Relevance 0.97 Pain Relevance 0.26
Experiments with the gut derived epithelial cell lines T84 and HT-29 showed that interferon gamma and TNF both independently and if applied together synergistically, reduce CFTR mRNA by destabilization of transcripts and with prolonged [> 24 hour] exposure also CFTR protein on the cell surface.
Negative_regulation (reduce) of CFTR mRNA in T84
16) Confidence 0.09 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.05 Pain Relevance 0.07

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