INT1511

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 1995
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.64
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 3
liver 3
lymphocytes 2
pituitary 2
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 2 100.00 Very High Very High Very High
Morphine 14 99.20 Very High Very High Very High
tolerance 1 98.72 Very High Very High Very High
anesthesia 2 98.40 Very High Very High Very High
Kinase C 1 95.56 Very High Very High Very High
Fibrositis 1 90.80 High High
rheumatoid arthritis 1 89.68 High High
backache 1 87.28 High High
agonist 1 85.96 High High
Intracerebroventricular 2 85.08 High High
Disease Link Frequency Relevance Heat
Cancer 3 99.60 Very High Very High Very High
Galactorrhea 3 97.28 Very High Very High Very High
Systemic Lupus Erythematosus 1 93.20 High High
Sleep Disorders 1 90.80 High High
Rheumatoid Arthritis 1 89.68 High High
Low Back Pain 1 87.60 High High
Experimental Arthritis 1 79.68 Quite High
Uveitis 2 78.08 Quite High
Autoimmune Disease 2 75.00 Quite High
Dysmenorrhea 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was suggested that the down-regulation in PRL binding to some extent at least resulted from receptor overstimulation caused by the morphine-induced elevation in the concentrations of the endogenous hormone.
Negative_regulation (down-regulation) of PRL Binding (binding) of associated with morphine
1) Confidence 0.59 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8545080 Disease Relevance 0 Pain Relevance 0.43
The decrease in prolactin binding was contrasted by elevated plasma levels of the hormone.
Negative_regulation (decrease) of prolactin Binding (binding) of in plasma
2) Confidence 0.58 Published 1994 Journal FEBS Lett. Section Abstract Doc Link 8307182 Disease Relevance 0 Pain Relevance 0.40
Cyclosporine A interferes with prolactin binding to its receptors on lymphocytes.
Negative_regulation (interferes) of prolactin Binding (binding) of in lymphocytes
3) Confidence 0.43 Published 1991 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 2068574 Disease Relevance 1.03 Pain Relevance 0.34
Significantly (P less than 0.05) reduced 125I-labeled ovine prolactin binding (mean, --16%) was also observed in liver samples exposed to a 30-min ether-induced rise in serum prolactin when compared to liver samples taken during the first minute of etherization.
Negative_regulation (reduced) of prolactin Binding (binding) of in liver
4) Confidence 0.43 Published 1978 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 210063 Disease Relevance 0 Pain Relevance 0.09
Significantly (P less than 0.01) reduced 125I-labeled ovine prolactin binding (mean, --22%), as a result of an ether anesthesia-reduced rise in serum prolactin, was observed in plasma membrane preparations of liver samples of female rats taken after 5 min of etherization when compared to samples taken from the same animals during the first minute of etherization.
Negative_regulation (reduced) of prolactin in plasma Binding (binding) of in liver associated with anesthesia
5) Confidence 0.43 Published 1978 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 210063 Disease Relevance 0 Pain Relevance 0.10
We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after alpha-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or alpha-diol.
Negative_regulation (decreased) of PRL Neg (not) Binding (concentrations) of in pituitary associated with fluoxetine
6) Confidence 0.43 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7524955 Disease Relevance 0 Pain Relevance 0.26
However, no decrease in PRL-binding was observed 15 min after i.c.v. injection of morphine.
Neg (no) Negative_regulation (decrease) of PRL Binding (binding) of associated with morphine
7) Confidence 0.43 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8545080 Disease Relevance 0 Pain Relevance 0.44
The diminished PRL response to all stimulation tests observed up to 6 months postoperatively might be explained by the persistence of a negative feedback effect from high PRL levels associated with the tumor.
Negative_regulation (persistence) of PRL Binding (associated) of associated with cancer
8) Confidence 0.38 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6775003 Disease Relevance 0.61 Pain Relevance 0.14

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