INT151101

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2008
Negated 1
Speculated 3
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.69
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR)
enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)
Anatomy Link Frequency
epithelial cell 2
nasal 1
CFTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 137 100.00 Very High Very High Very High
sodium channel 39 100.00 Very High Very High Very High
fibrosis 31 100.00 Very High Very High Very High
agonist 31 100.00 Very High Very High Very High
potassium channel 8 100.00 Very High Very High Very High
cytokine 84 98.40 Very High Very High Very High
chemokine 8 97.92 Very High Very High Very High
Inflammatory mediators 80 97.44 Very High Very High Very High
adenocard 31 96.36 Very High Very High Very High
cINOD 7 90.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 228 100.00 Very High Very High Very High
Cystic Fibrosis 31 100.00 Very High Very High Very High
Nasal Polyps 19 98.76 Very High Very High Very High
Polyps 10 93.72 High High
Disease 36 93.60 High High
Sinusitis 10 85.60 High High
Congenital Anomalies 16 78.60 Quite High
Inflammatory Bowel Disease 16 73.96 Quite High
Endotoxemia 4 72.80 Quite High
Cancer 20 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate the effects of ibuprofen on CFTR function under different conditions.
Spec (investigate) Regulation (effects) of CFTR
1) Confidence 0.62 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.53 Pain Relevance 0.35
IFN gamma reduced Na/K/2Cl-cotransporter and Na/K ATPase expression without altering CFTR levels in T84 intestinal epithelial cells [91].
Neg (without) Regulation (altering) of CFTR in epithelial cells
2) Confidence 0.36 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.07 Pain Relevance 0.03
The aim of the present study was to examine the effects of ion transport modulators, including purinergic agonists, NO donors, and the CFTR chloride channel activator on nasal polyps in situ using a voltage-sensitive vibrating probe technique.


Spec (examine) Regulation (effects) of CFTR in nasal associated with agonist and nasal polyps
3) Confidence 0.31 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 1.04 Pain Relevance 0.23
The keywords used for literature search were "ion transport", which was combined with "inflammation" and the terms "sodium channel", "chloride channel", "potassium channel", "CFTR" and "ATPase" combined with the terms "cytokine", "chemokine", "prostaglandin", "leukotriene" and "kinine".
Regulation (used) of CFTR associated with chemokine, inflammation, sodium channel, potassium channel and cytokine
4) Confidence 0.26 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.77 Pain Relevance 0.51
CFTR Cystic fibrosis transmembrane conductance regulator
Regulation (regulator) of CFTR associated with fibrosis and cystic fibrosis
5) Confidence 0.26 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.83 Pain Relevance 0.37
In vitro studies have investigated the effects of CFTR dysfunction in cystic fibrosis [CFTR mutation] patients on cytokine secretion in white blood cell and respiratory epithelial cell populations.
Spec (investigated) Regulation (effects) of CFTR in epithelial cell associated with fibrosis, cystic fibrosis and cytokine
6) Confidence 0.26 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.45 Pain Relevance 0.41

General Comments

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