INT151102

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 15.27
Pain Relevance 5.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR)
enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)
Anatomy Link Frequency
epithelial cells 3
ducts 2
gut 2
lumen 1
smooth muscle cells 1
CFTR (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 229 100.00 Very High Very High Very High
cINOD 23 99.98 Very High Very High Very High
agonist 88 99.48 Very High Very High Very High
Inflammation 390 98.40 Very High Very High Very High
cytokine 233 97.08 Very High Very High Very High
bradykinin 110 94.00 High High
Crohn's disease 11 93.28 High High
alcohol 3 90.56 High High
Chronic pancreatitis 97 87.96 High High
sodium channel 108 87.84 High High
Disease Link Frequency Relevance Heat
Cystic Fibrosis 228 100.00 Very High Very High Very High
Heart Rate Under Development 122 99.92 Very High Very High Very High
INFLAMMATION 644 99.86 Very High Very High Very High
Disease 130 99.12 Very High Very High Very High
Exocrine Pancreatic Insufficiency 17 98.68 Very High Very High Very High
Diarrhoea 88 98.60 Very High Very High Very High
Bone Cancer 25 96.32 Very High Very High Very High
Sepsis 46 95.28 Very High Very High Very High
Asthma 12 95.28 Very High Very High Very High
Meningitis 33 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonsteroidal anti-inflammatory drugs upregulate function of wild-type and mutant CFTR.
Positive_regulation (upregulate) of CFTR associated with inflammation and cinod
1) Confidence 0.61 Published 2008 Journal Eur. Respir. J. Section Title Doc Link 18385167 Disease Relevance 0.63 Pain Relevance 0.44
On the other hand, there are reports that the nitric oxide (NO) inhibits Na+ absorption in rat cortical collecting ducts (5) and rat distal lung epithelium (6), while NO activates the cystic fibrosis transmembrane conductance regulator (CFTR) current in human T lymphocytes (7).
Positive_regulation (activates) of CFTR in ducts associated with fibrosis and cystic fibrosis
2) Confidence 0.55 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 1.18 Pain Relevance 0.19
On the other hand, there are reports that the nitric oxide (NO) inhibits Na+ absorption in rat cortical collecting ducts (5) and rat distal lung epithelium (6), while NO activates the cystic fibrosis transmembrane conductance regulator (CFTR) current in human T lymphocytes (7).
Positive_regulation (activates) of cystic fibrosis transmembrane conductance regulator in ducts associated with fibrosis and cystic fibrosis
3) Confidence 0.55 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 1.18 Pain Relevance 0.19
Addition of ibuprofen to the extracellular solution caused a rapid inhibition of CFTR activity in IB3-8-3-7 cells in the presence of a high intracellular concentration of cAMP, whereas ibuprofen enhanced the CFTR conductance at low levels of cAMP.
Positive_regulation (conductance) of CFTR
4) Confidence 0.50 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.57 Pain Relevance 0.40
Paradoxically, ibuprofen inhibits ligand-stimulated CF transmembrance conductance regulator (CFTR) activity.
Positive_regulation (ligand-stimulated) of CFTR associated with fibrosis
5) Confidence 0.50 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.55 Pain Relevance 0.36
Paradoxically, ibuprofen inhibits ligand-stimulated CF transmembrance conductance regulator (CFTR) activity.
Positive_regulation (ligand-stimulated) of CF transmembrance conductance regulator associated with fibrosis
6) Confidence 0.50 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.55 Pain Relevance 0.36
It is noteworthy that CFTR is expressed in vascular smooth muscle cells and activation of CFTR chloride channels regulates contraction and relaxation of smooth muscle cells; disruption of the CFTR gene prevents cAMP-dependent vasorelaxation in experimental studies [65].
Positive_regulation (activation) of CFTR in smooth muscle cells
7) Confidence 0.42 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995617 Disease Relevance 0.10 Pain Relevance 0.03
TGF beta1 was found to lead to perinuclear accumulation of CFTR protein and reduced chloride secretory responses to cAMP stimulating agents [82].
Positive_regulation (accumulation) of CFTR protein
8) Confidence 0.41 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.32 Pain Relevance 0.23
CFTR activation by cAMP in alveolar epithelial cells has been shown to be a condition for apical sodium influx into alveolar epithelial cells through ENaC by hyperpolarisation [18].
Positive_regulation (activation) of CFTR in epithelial cells
9) Confidence 0.41 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.35 Pain Relevance 0.03
It upregulated CFTR mRNA levels at a dose of 0.25 ng/ml and inhibited CFTR mRNA and protein expression at higher doses [1 ng/ml] in T 84 cells [86].
Positive_regulation (upregulated) of CFTR mRNA
10) Confidence 0.41 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.14 Pain Relevance 0.08
In the gut NO increased intracellular cGMP levels, a second messenger, which induced Cl -secretion by stimulation of CFTR through cGMP-regulated protein kinase G type II [68].
Positive_regulation (stimulation) of CFTR in gut
11) Confidence 0.41 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.06 Pain Relevance 0.28
All forms of inflammatory diarrhoea are associated with hypersecretion of chloride into the gut lumen by activation of CFTR at the apical membrane of colonocytes drawing water with it by osmotic effects.
Positive_regulation (activation) of CFTR in lumen associated with diarrhoea and inflammation
12) Confidence 0.41 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 1.48 Pain Relevance 0.28
G542X is a Class I mutation that results in the complete failure to synthesize functional cystic fibrosis transmembrane conductance regulator (CFTR) and is usually associated with pancreatic insufficiency.
Positive_regulation (conductance) of CFTR associated with fibrosis, exocrine pancreatic insufficiency and cystic fibrosis
13) Confidence 0.37 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936924 Disease Relevance 1.36 Pain Relevance 0.34
Although DIDS and DPC are non-specific anion channel blockers, current pharmacology indicates that DIDS does not act on the CFTR chloride channel, even at high concentrations (15), and DPC induces a voltage-dependent blockade of CFTR when used at micromolar concentrations (16).
Neg (not) Positive_regulation (act) of CFTR
14) Confidence 0.32 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 0.26 Pain Relevance 0.07
CFTR dysfunction was also induced through Na/K ATPase inhibition by ouabain in airway epithelial cells in another experiment [15].
Positive_regulation (induced) of CFTR in epithelial cells
15) Confidence 0.29 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.60 Pain Relevance 0.03
Therefore, all patients with onset of the disease in childhood and early adulthood should be screened for a pathological sweat chloride test and subsequently for the most common CFTR mutations of their population.
Positive_regulation (screened) of CFTR in sweat associated with disease
16) Confidence 0.29 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.22 Pain Relevance 0.41
Activated CFTR can inhibit ENaC [55] and therefore sodium absorption in the gut and this may be the main mechanism of fluid loss in diarrhoea by reduction in sodium driven fluid absorption.
Positive_regulation (Activated) of CFTR in gut associated with diarrhoea
17) Confidence 0.27 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 1.33 Pain Relevance 0.24
The adenylate cyclase increases cAMP levels, which activate CFTR via proteinkinase A.
Positive_regulation (activate) of CFTR
18) Confidence 0.27 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.64 Pain Relevance 0.32
CFTR and CaCC seem to regulate each others activity: CFTR activation or increased expression is associated with a reduction in CaCC function.
Positive_regulation (activation) of CFTR
19) Confidence 0.27 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.08 Pain Relevance 0.07
Experiments with alveolar epithelial cells in vitro have demonstrated that CFTR in these cells can be activated by the beta agonists terbutaline [126], which is available as an aerosol for application in patients and licenced as asthma treatment.
Positive_regulation (activated) of CFTR in epithelial cells associated with asthma and agonist
20) Confidence 0.27 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.73 Pain Relevance 0.19

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