INT151111

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 33
Total Number 35
Disease Relevance 33.60
Pain Relevance 30.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leg 2
blood 1
spinal 1
spinal cord 1
arm 1
Pain1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 3190 100.00 Very High Very High Very High
Pain score 102 100.00 Very High Very High Very High
backache 44 100.00 Very High Very High Very High
Lasting pain 42 100.00 Very High Very High Very High
Arthritis 637 99.98 Very High Very High Very High
substance P 8 99.98 Very High Very High Very High
Central nervous system 39 99.96 Very High Very High Very High
Mechanosensation 6 99.64 Very High Very High Very High
Mcgill questionnaire 84 99.60 Very High Very High Very High
Spinal cord 16 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 3309 100.00 Very High Very High Very High
Low Back Pain 52 100.00 Very High Very High Very High
Syndrome 6 100.00 Very High Very High Very High
Arthritis 695 99.98 Very High Very High Very High
Diabetic Neuropathy 45 99.52 Very High Very High Very High
Disease 97 98.76 Very High Very High Very High
Rheumatoid Arthritis 88 98.70 Very High Very High Very High
INFLAMMATION 116 98.56 Very High Very High Very High
Osteoarthritis 182 98.22 Very High Very High Very High
Stress 32 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas the cDNA alleles Pain1-Da, Sa and P18a contained all three SNPs, the allele StPain1-a (AAA50305) contained only A1544.
Gene_expression (alleles) of Pain1
1) Confidence 0.40 Published 2010 Journal BMC Plant Biol Section Body Doc Link PMC3012049 Disease Relevance 0.14 Pain Relevance 0.09
Interestingly, the three SNPs diagnostic for Pain-1 alleles of group a (C552, A718 and A1544 ) differed in their associations.
Gene_expression (alleles) of Pain-1 associated with pain
2) Confidence 0.35 Published 2010 Journal BMC Plant Biol Section Body Doc Link PMC3012049 Disease Relevance 0.17 Pain Relevance 0.10
Empirical evidence has suggested that tricyclic antidepressant (TCA) medications are useful as treatment for chronic pain syndromes, including diabetic neuropathy.
Gene_expression (syndromes) of pain associated with syndrome, diabetic neuropathy, lasting pain and tricyclic antidepressant
3) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.47 Pain Relevance 1.43
In the Goldstein et al (2005) trial, subjects in the 20 mg arm did not show significant pain reduction relative to placebo.
Gene_expression (reduction) of pain in arm associated with pain
4) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.25 Pain Relevance 1.17
Central sensitization refers to neural plasticity and functional changes in the central nervous system (CNS) pain processing pathways that may result in a state of heightened sensitivity to painful stimuli, increased perception of non-painful stimuli as painful, and in some cases, the development of persistent pain in the absence of any stimulus (Woolf and Mannion 1999).
Gene_expression (processing) of pain in central nervous system associated with pain, central sensitization, lasting pain and central nervous system
5) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.60 Pain Relevance 1.52
Several pain-related gene expressions were investigated in the spinal cord using reverse transcriptase-polymerase chain reaction analysis.
Spec (investigated) Gene_expression (expressions) of pain-related in spinal cord
6) Confidence 0.18 Published 2010 Journal Neurol. Res. Section Body Doc Link 20034454 Disease Relevance 0.09 Pain Relevance 0
From the 1023 returned questionnaires, 13 were discarded due to incorrect coding and a further 22 were discarded due to missing relevant baseline data and 4 because they appeared to belong to patients who had neither LBP nor leg pain.
Neg (neither) Gene_expression (had) of leg pain in leg associated with pain and backache
7) Confidence 0.10 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2588613 Disease Relevance 0.43 Pain Relevance 0.43
BMI was retained in the final model together with leg pain and better at 2nd visit.


Gene_expression (retained) of leg pain in leg associated with pain
8) Confidence 0.09 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2588613 Disease Relevance 0.45 Pain Relevance 0.45
Some of the patients could provide limited information about pain at the moment and this was demonstrated during the expert's clinical examination and during the morning sessions, while the nurses wash and dress the patients, which caused some patients to express pain complaints, which then again lead to positive expert pain score and positive score on the Doloplus-2 item about pain complaints.
Gene_expression (express) of pain associated with pain and pain score
9) Confidence 0.08 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 0.80 Pain Relevance 0.80
As a validation of the evaluations performed by the pain expert, two geriatricians with expertise in pain presentation in demented patients observed the pain expert while he evaluated 15 consecutive patients.
Gene_expression (presentation) of pain associated with pain
10) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 1.27 Pain Relevance 1.27
Both the expert's pain score and the nurses' Doloplus-2 scores were based upon the same time interval and all assessors had access to information about the patient's medical condition during the past 24 hours.
Gene_expression (scores) of pain associated with pain score
11) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 1.51 Pain Relevance 1.51
Pain was defined as and limited to somatic pain, i.e. a symptom generally relieved by analgesics, and consequently excluding what the pain expert interpreted as existential pain.


Gene_expression (expert) of pain associated with pain, analgesic and somatic pain
12) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 1.20 Pain Relevance 0.98
The expert performed a comprehensive evaluation of the patient, but his pain ratings focused on what he judged as somatic pain intensity.
Gene_expression (ratings) of pain associated with pain and somatic pain
13) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 1.38 Pain Relevance 1.10
The aim was to test the Doloplus-2 in patients who were unable to self-report and therefore we compared nurses' Doloplus-2 scores to pain scores (pain criterion) given by pain experts who examined these patients (R2 = 62%).
Gene_expression (experts) of pain associated with pain and pain score
14) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 0.47 Pain Relevance 0.47
Thus, it may be hypothesized that valid Doloplus-2 administration and interpretation demand training in geriatrics and knowledge of pain presentation in cognitively impaired patients.
Gene_expression (presentation) of pain associated with pain
15) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 0.50 Pain Relevance 0.58
As a validation of the evaluations performed by the pain expert, two geriatricians with expertise in pain presentation in demented patients observed the pain expert while he evaluated 15 consecutive patients.
Gene_expression (expert) of pain associated with pain
16) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 1.38 Pain Relevance 1.38
Some of the patients could provide limited information about pain at the moment and this was demonstrated during the expert's clinical examination and during the morning sessions, while the nurses wash and dress the patients, which caused some patients to express pain complaints, which then again lead to positive expert pain score and positive score on the Doloplus-2 item about pain complaints.
Gene_expression (complaints) of pain associated with pain and pain score
17) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 0.81 Pain Relevance 0.81
The Doloplus-2 was originally developed for pain assessment in children and the inclusion of the psychosocial items may come from this origin.
Gene_expression (assessment) of pain associated with pain
18) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 0.57 Pain Relevance 0.63
In order to discuss the discrepancy between Doloplus-2 and expert score, the pain expert, the GN and the Doloplus-2 administrators at one nursing home were consulted.
Gene_expression (expert) of pain associated with pain
19) Confidence 0.07 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 1.01 Pain Relevance 0.92
However, unexpectedly it turned out that the sample had lower average levels of pain, as rated by the experts than, the sample in the pilot study.
Gene_expression (levels) of pain associated with pain
20) Confidence 0.06 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC2234400 Disease Relevance 0.79 Pain Relevance 0.84

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