INT151115

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.12
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 6 97.80 Very High Very High Very High
Inflammation 41 89.16 High High
ischemia 4 88.80 High High
tolerance 1 58.72 Quite High
Inflammatory response 2 36.64 Quite Low
anesthesia 2 25.00 Low Low
aspirin 1 25.00 Low Low
Kinase C 21 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 4 98.38 Very High Very High Very High
Arrhythmias 2 Under Development 3 98.06 Very High Very High Very High
Apoptosis 60 98.02 Very High Very High Very High
Heart Rate Under Development 3 97.38 Very High Very High Very High
Arrhythmia Under Development 3 96.54 Very High Very High Very High
Periodontitis 30 92.40 High High
Periodontal Disease 9 89.96 High High
INFLAMMATION 45 89.16 High High
Cv Unclassified Under Development 4 88.80 High High
Cancer 2 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infarct size, bax expression, number of ventricular ectopic beats (VEB), duration of ventricular tachycardia (VT) and ventricular fibrillation (VF) were significantly decreased in ischemic preconditioning and 3-NP pretreatment groups, whereas bcl-2 values were not markedly changed in these groups during occlusion period.
Neg (not) Regulation (changed) of Regulation (values) of bcl-2 associated with heart rate under development, arrhythmias 2 under development and arrhythmia under development
1) Confidence 0.21 Published 2008 Journal Life Sci. Section Abstract Doc Link 18387637 Disease Relevance 1.20 Pain Relevance 0.18
From the results, we identified proapoptotic transcriptional changes, including up regulation of proapoptotic Bax and down regulation of antiapoptotic Bcl-2, using a Western blot assay.
Regulation (regulation) of Regulation (regulation) of Bcl-2
2) Confidence 0.20 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 1.35 Pain Relevance 0.17
However, taurine treatment inhibited As-induced up-regulation of Bad, Bax and down-regulation of Bcl-2, Bcl-xL.
Regulation (regulation) of Regulation (regulation) of Bcl-2
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.76 Pain Relevance 0
Apoptosis in gastric cancer cells expressing wild-type p53 is induced through up-regulation of bax and down-regulation of bcl-2 and that regulation of the bax-bcl-2 heterodimer may be a major target of NSAIDs.
Regulation (regulation) of Regulation (regulation) of bcl-2 associated with cinod, apoptosis and stomach cancer
4) Confidence 0.03 Published 2008 Journal Cancer Invest. Section Abstract Doc Link 18798056 Disease Relevance 0.80 Pain Relevance 0.53

General Comments

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