INT151123

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 21.76
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
choroid plexus 7
macrophage 4
granulocyte 4
hepatocytes 2
CSF 2
Csf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 55 100.00 Very High Very High Very High
Nerve growth factor 54 99.60 Very High Very High Very High
Inflammation 29 95.72 Very High Very High Very High
Hyperalgesia 2 90.32 High High
tail-flick 4 88.80 High High
intrathecal 5 86.96 High High
cytokine 19 82.24 Quite High
Central grey 6 82.24 Quite High
Inflammatory response 4 77.76 Quite High
Antinociceptive 4 76.52 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 55 100.00 Very High Very High Very High
Cancer 35 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Disease 902 99.88 Very High Very High Very High
Hydrocephalus 127 99.86 Very High Very High Very High
African Trypanosomiasis 13 99.84 Very High Very High Very High
Cv General 2 Under Development 33 99.64 Very High Very High Very High
Aging 24 99.56 Very High Very High Very High
Normal Pressure Hydrocephalus 528 99.16 Very High Very High Very High
Dementia 77 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-kappaB nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway.
Negative_regulation (suppressed) of Gene_expression (production) of GM-CSF in hepatocytes
1) Confidence 0.53 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.27 Pain Relevance 0.13
First, there is a trend toward decreased CSF production, with a concomitant decrease in CSF turnover [13].
Negative_regulation (decreased) of Gene_expression (production) of CSF
2) Confidence 0.40 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.32 Pain Relevance 0.07
Age-related accumulations of amyloid in the choroid plexus and meninges, fibrosis, thickening of the basement membrane, and senescent changes in the choroidal epithelium and choroidal vasculature probably play a role both in decreased CSF production and decreased CSF absorption in normal aging, in NPH and in AD [1,12,15,16].
Negative_regulation (decreased) of Gene_expression (production) of CSF in thickening associated with fibrosis, normal pressure hydrocephalus, aging, alzheimer's dementia and disease
3) Confidence 0.40 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.54 Pain Relevance 0.09
Reduced CSF production and turnover have been demonstrated in both AD and NPH patients [1,10,17].
Negative_regulation (Reduced) of Gene_expression (production) of CSF associated with normal pressure hydrocephalus and disease
4) Confidence 0.40 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.61 Pain Relevance 0.12
If CSF failure (diminished CSF production and impaired choroid plexus transport) predominates, then AD may manifest initially.
Negative_regulation (diminished) of Gene_expression (production) of CSF in choroid plexus associated with disease
5) Confidence 0.40 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 2.04 Pain Relevance 0.03
Moreover, ethanol fractions potently suppressed the expression of cycloxygenase (COX)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are stimulated by LPS in RAW264.7 cells.
Negative_regulation (suppressed) of Gene_expression (expression) of granulocyte-macrophage colony-stimulating factor in granulocyte
6) Confidence 0.39 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688813 Disease Relevance 0.52 Pain Relevance 0.39
Moreover, ethanol fractions potently suppressed the expression of cycloxygenase (COX)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are stimulated by LPS in RAW264.7 cells.
Negative_regulation (suppressed) of Gene_expression (expression) of GM-CSF in granulocyte
7) Confidence 0.39 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688813 Disease Relevance 0.52 Pain Relevance 0.39
The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-alpha, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression.
Negative_regulation (suppressed) of Gene_expression (expression) of granulocyte-macrophage colony-stimulating factor in macrophage associated with necrosis and cancer
8) Confidence 0.38 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.38 Pain Relevance 0.20
The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-alpha, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression.
Negative_regulation (suppressed) of Gene_expression (expression) of GM-CSF in macrophage associated with necrosis and cancer
9) Confidence 0.38 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.38 Pain Relevance 0.20
The latter is the result of dilution within the third ventricle by inflowing unlabeled CSF from the contralateral lateral ventricle and by production of fresh CSF by the third ventricle choroid plexus.
Negative_regulation (inflowing) of Gene_expression (production) of CSF in third ventricle choroid plexus
10) Confidence 0.30 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.14 Pain Relevance 0.13
Patients with both diseases have reduced cerebrospinal fluid (CSF) production and decreased CSF turnover that may be associated with a decreased ability to clear potentially toxic metabolites, such as amyloid beta-peptides (A?)
Negative_regulation (reduced) of Gene_expression (production) of CSF in CSF associated with alzheimer's dementia and disease
11) Confidence 0.30 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.43 Pain Relevance 0
In an animal model of NPH, kaolin-induced hydrocephalus, CSFP is initially elevated but soon returns to the physiological range after ventricular dilatation, decreased CSF production and other compensatory events occur [29].
Negative_regulation (decreased) of Gene_expression (production) of CSF associated with normal pressure hydrocephalus and hydrocephalus
12) Confidence 0.30 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.21 Pain Relevance 0.03
In a rat model of FGF-2-induced hydrocephalus, both decreased CSF production and increased fibrosis of the CSF absorption pathways were demonstrated [20].
Negative_regulation (decreased) of Gene_expression (production) of CSF associated with fibrosis and hydrocephalus
13) Confidence 0.29 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.84 Pain Relevance 0.17
Age-related accumulations of amyloid in the choroid plexus and meninges, fibrosis, thickening of the basement membrane, and senescent changes in the choroidal epithelium and choroidal vasculature probably play a role both in decreased CSF production and decreased CSF absorption in normal aging, in NPH and in AD [1,12,15,16].
Negative_regulation (decreased) of in meninges Gene_expression (absorption) of CSF in choroid plexus associated with fibrosis, normal pressure hydrocephalus, aging, alzheimer's dementia and disease
14) Confidence 0.29 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.50 Pain Relevance 0.09
If CSF failure (diminished CSF production and impaired choroid plexus transport) predominates, then AD may manifest initially.
Negative_regulation (diminished) of Gene_expression (production) of CSF in choroid plexus associated with disease
15) Confidence 0.29 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 2.05 Pain Relevance 0.03
In a rat model of FGF-2-induced hydrocephalus, both decreased CSF production and increased fibrosis of the CSF absorption pathways were demonstrated [20].
Negative_regulation (decreased) of Gene_expression (production) of CSF associated with fibrosis and hydrocephalus
16) Confidence 0.29 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.82 Pain Relevance 0.17
Since NGF and NT-3 CSF concentrations were also related to overall CSF protein levels in hydrocephalic children, some of the NGF and NT-3 molecules detected in CSF may actually be derived from neurotrophins circulating in the blood.
Negative_regulation (derived) of Gene_expression (detected) of CSF in blood associated with nerve growth factor
17) Confidence 0.28 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.56 Pain Relevance 0.72
Age-related accumulations of amyloid in the choroid plexus and meninges, fibrosis, thickening of the basement membrane, and senescent changes in the choroidal epithelium and choroidal vasculature probably play a role both in decreased CSF production and decreased CSF absorption in normal aging, in NPH and in AD [1,12,15,16].
Negative_regulation (decreased) of Gene_expression (absorption) of CSF in choroid plexus associated with fibrosis, normal pressure hydrocephalus, aging, alzheimer's dementia and disease
18) Confidence 0.10 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.50 Pain Relevance 0.09
A primed-continuous ICV infusion of HN, F6AHN (total dose of 20 ug), dimerization deficient (DD) HN, STAT-3 inhibitor (75 pmol) , or artificial cerebro-spinal fluid (aCSF) was initiated at t?
Negative_regulation (inhibitor) of Gene_expression (infusion) of aCSF in spinal
19) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.27 Pain Relevance 0.07
Although SOREMPs are also observed in HAT, our group has demonstrated that they do not depend on a lack of hypocretin availability since the concentration of CSF hypocretin was found to be near normal control values in HAT patients [33].
Negative_regulation (values) of Gene_expression (concentration) of CSF associated with african trypanosomiasis
20) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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