INT151125

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k7) nucleus (Map2k7) response to stress (Map2k7)
cytoplasm (Map2k7)
Anatomy Link Frequency
hepatocytes 2
Map2k7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 97.36 Very High Very High Very High
anesthesia 2 96.48 Very High Very High Very High
Inflammation 4 88.60 High High
Inflammatory response 2 63.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 88.60 High High
Necrosis 2 84.96 Quite High
Cancer 2 84.60 Quite High
Sepsis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation.
Negative_regulation (suppressing) of Localization (translocation) of MAPK/ERK in hepatocytes associated with cytokine
1) Confidence 0.08 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 18387647 Disease Relevance 0.30 Pain Relevance 0.32
In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and IkappaBalpha, as well as the nuclear translocation of NF-kappaB primed by LPS.
Negative_regulation (attenuated) of Localization (translocation) of MAPK/ERK
2) Confidence 0.08 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.31 Pain Relevance 0.19

General Comments

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