INT151127

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.10
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Litaf) extracellular region (Litaf) Golgi apparatus (Litaf)
signal transducer activity (Litaf)
Litaf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 15 100.00 Very High Very High Very High
Inflammatory mediators 2 99.68 Very High Very High Very High
COX-2 inhibitor 3 98.60 Very High Very High Very High
cytokine 6 87.88 High High
anesthesia 2 79.56 Quite High
ischemia 17 74.32 Quite High
Central nervous system 12 73.96 Quite High
Pain 1 63.64 Quite High
Inflammatory response 2 55.36 Quite High
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 19 100.00 Very High Very High Very High
Cancer 5 98.00 Very High Very High Very High
Necrosis 5 97.72 Very High Very High Very High
Stroke 23 84.56 Quite High
Brain Injury 12 81.44 Quite High
Nonarteritic Anterior Ischaemic Optic Neuropathy 12 80.64 Quite High
Body Weight 1 77.00 Quite High
Cv Unclassified Under Development 11 74.32 Quite High
Arteritic Anterior Ischaemic Optic Neuropathy 2 70.08 Quite High
Ganglion Cysts 5 67.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
rAION induces an early increase in estrogen expressed transcript-1 (EET-1), but EET-1 expression is not affected by systemic estrogen pretreatment.
Neg (not) Regulation (affected) of Gene_expression (expression) of EET-1
1) Confidence 0.18 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2185481 Disease Relevance 0.79 Pain Relevance 0.10
However, celecoxib had no effect on COX-2 protein levels or LPS-induced expression of the inflammatory mediators interleukin-1beta, tumour necrosis factor-alpha or inducible nitric-oxide synthase.
Neg (no) Regulation (effect) of Gene_expression (expression) of LPS-induced associated with necrosis, inflammatory mediators and cancer
2) Confidence 0.12 Published 2009 Journal Int. J. Androl. Section Abstract Doc Link 18522674 Disease Relevance 0.61 Pain Relevance 0.28
Pretreatment with 100 microM PPF for 24 h prior to LPS stimulation was performed to investigate the modulatory effect on LPS-induced inflammatory gene production.
Spec (investigate) Regulation (effect) of Gene_expression (production) of LPS-induced associated with inflammation
3) Confidence 0.04 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.36 Pain Relevance 0.22
None of these compounds modify the LPS-induced mPGES-1 expression (data not shown).


Regulation (modify) of Gene_expression (expression) of LPS-induced
4) Confidence 0.02 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.35 Pain Relevance 0.12

General Comments

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