From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 49 94.84 High High
Spinal cord 9 92.48 High High
Inflammation 3 86.52 High High
intrathecal 13 84.88 Quite High
Spontaneous pain 8 75.80 Quite High
cytokine 17 73.04 Quite High
anesthesia 3 64.72 Quite High
Inflammatory response 1 36.00 Quite Low
Pain 14 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Cancer 54 94.64 High High
Necrosis 1 93.80 High High
Cancer 19 93.44 High High
INFLAMMATION 4 86.52 High High
Polycystic Ovary Syndrome 7 79.84 Quite High
Pain 26 75.80 Quite High
Neuropathic Pain 20 5.00 Very Low Very Low Very Low
Hypersensitivity 17 5.00 Very Low Very Low Very Low
Inflammatory Pain 5 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR4 siRNA439 treatment caused a significant decrease (58% ± 8 in IBCP group (Fig. 6A), 43% ± 7 in WBCP group (Fig. 6B) (n = 4)) in the TLR4 mRNA level compared with that in normal rats.
Positive_regulation (caused) of Negative_regulation (decrease) of TLR4 mRNA
1) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.66 Pain Relevance 0.57
Western blotting analysis showed that PPF pretreatment potentiated the LPS-induced TLR-4 downregulation.
Positive_regulation (potentiated) of Negative_regulation (downregulation) of TLR-4
2) Confidence 0.13 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.35 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools