INT151166

Context Info Confidence 0.40 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.54 Pain Relevance 0.35

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency aortas 2 Pten (Mus musculus)

Pain Link Frequency Relevance Heat Clonidine 5 99.82 carbamazepine 1 5.00 Substantia nigra 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 13 99.84 Dna Damage 1 96.28 Cancer 4 91.84 Starvation 6 85.68 Apoptosis 5 79.36 Tuberous Sclerosis 1 55.16 Stress 4 52.64 Alzheimer's Dementia 18 5.00 Neurodegenerative Disease 16 5.00 Disease 15 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression level of clonidine-induced phosphorylated PTEN (phosphatase and tensin homolog deleted on chromosome ten) was significantly increased in diabetic aortas, but chronic simvastatin did not affect it.

Positive_regulation (increased) of Phosphorylation (phosphorylated) of PTEN in aortas associated with diabetes mellitus and clonidine

1) Confidence 0.40 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.91 Pain Relevance 0.35

This can stimulate autophagy by activating AMPK or by upregulating phosphatase and tensin homologue (PTEN, a PIP3 3?

Positive_regulation (upregulating) of Phosphorylation (phosphatase) of PTEN

2) Confidence 0.10 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.63 Pain Relevance 0

General Comments

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