INT151167

Context Info Confidence 0.72 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.69 Pain Relevance 0.35

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency aortas 1 heart 1 Pten (Mus musculus)

Pain Link Frequency Relevance Heat Clonidine 5 99.82 carbamazepine 1 5.00 Substantia nigra 1 5.00 Pain 1 5.00 isoflurane 1 5.00 imagery 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 18 99.92 Diabetes Mellitus 14 96.36 Dna Damage 1 95.76 Cancer 5 91.32 Starvation 6 85.68 Apoptosis 5 79.36 Hypertrophy 15 61.28 Tuberous Sclerosis 1 54.64 Stress 5 52.64 Alzheimer's Dementia 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further, even though complete knockout of PTEN in muscle led to a reduction in insulin-stimulated phosphorylation of PKB in the EDL and increased wet mass in the TA and heart, the response to overload was unaltered.

Phosphorylation (phosphorylation) of PTEN in heart associated with targeted disruption

1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.16 Pain Relevance 0

The expression level of clonidine-induced phosphorylated PTEN (phosphatase and tensin homolog deleted on chromosome ten) was significantly increased in diabetic aortas, but chronic simvastatin did not affect it.

Phosphorylation (phosphorylated) of PTEN in aortas associated with diabetes mellitus and clonidine

2) Confidence 0.65 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.91 Pain Relevance 0.35

This can stimulate autophagy by activating AMPK or by upregulating phosphatase and tensin homologue (PTEN, a PIP3 3?

Phosphorylation (phosphatase) of PTEN

3) Confidence 0.16 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.62 Pain Relevance 0

General Comments

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