INT151169

Context Info Confidence 0.45 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 15 Total Number 17 Disease Relevance 12.88 Pain Relevance 1.53

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency muscle 6 MCF-7 6 dendrites 3 neurons 3 DA neurons 2 Pten (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 575 100.00 Clonidine 4 100.00 midbrain 75 96.08 isoflurane 3 94.12 cerebral cortex 5 83.68 Hippocampus 5 82.08 Inflammation 152 70.20 agonist 23 69.28 Ventral tegmentum 40 69.08 Substantia nigra 40 41.36

Disease Link Frequency Relevance Heat Cancer 405 100.00 Diabetes Mellitus 17 99.84 Hypertrophy 60 99.48 Hepatocellular Cancer 72 99.36 Death 66 98.40 Breast Cancer 10 97.76 Apoptosis 197 97.44 Targeted Disruption 75 95.00 Brain Tumor 5 94.56 Skin Cancer 12 93.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, while the increased activation of PKB in the overloaded PLN muscle of the PTEN?

Positive_regulation (activation) of Gene_expression (muscle) of PTEN in muscle

1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.27 Pain Relevance 0

For example, the use of a Nestin promoter to induce Pten deletion in neural stem cells and glial progenitors resulted in neonatal death, as mice showed enlarged and histoarchitecturally abnormal brains [10].

Positive_regulation (induce) of Gene_expression (deletion) of Pten in brains associated with death

2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.47 Pain Relevance 0.11

Pten deletion leads to neuronal hypertrophy and increased number of TH positive neurons and dendrites in the ventral midbrain

Positive_regulation (leads) of Gene_expression (deletion) of Pten in dendrites associated with hypertrophy and midbrain

3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.42 Pain Relevance 0.32

In this study, we have shown Pten deletion in differentiated DA neurons causes a significant increase in the number and size of surviving neurons in both the mesolimbic and nigrostriatal projecting pathways.

Positive_regulation (increase) of Gene_expression (deletion) of Pten in DA neurons associated with dopamine

4) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.57 Pain Relevance 0.28

PTEN is widely distributed in the brain and is preferentially expressed in neurons, where it localizes to both the nucleus and cytoplasm [4]–[7].

Positive_regulation (distributed) of Gene_expression (expressed) of PTEN in neurons

5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 1.19 Pain Relevance 0

The expression level of clonidine-induced phosphorylated PTEN (phosphatase and tensin homolog deleted on chromosome ten) was significantly increased in diabetic aortas, but chronic simvastatin did not affect it.

Positive_regulation (increased) of Gene_expression (expression) of PTEN in aortas associated with diabetes mellitus and clonidine

6) Confidence 0.40 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.93 Pain Relevance 0.35

Crossing muscle specific PTEN knockouts with the AMPK?

Positive_regulation (muscle) of Gene_expression (knockouts) of PTEN in muscle

7) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.41 Pain Relevance 0

Generation of Muscle Specific PTEN null mice

Positive_regulation (Generation) of Gene_expression (Generation) of PTEN in Muscle

8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.16 Pain Relevance 0.05

The boosting of activity of doxorubicin when combined with YSL may result from the increased expression of PTEN to increase the sensitivity of BEL-7402 cells to doxorubicin.

Positive_regulation (increased) of Gene_expression (expression) of PTEN

9) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2601048 Disease Relevance 1.44 Pain Relevance 0

Over-expression of PTEN could increase the sensitivity to doxorubicin in human breast cancer MCF-7 cells [22].

Positive_regulation (Over) of Gene_expression (Over) of PTEN in MCF-7 associated with breast cancer

10) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2601048 Disease Relevance 1.62 Pain Relevance 0

Over-expression of PTEN could increase the sensitivity to doxorubicin in human breast cancer MCF-7 cells [22].

Positive_regulation (Over) of Gene_expression (expression) of PTEN in MCF-7 associated with breast cancer

11) Confidence 0.21 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2601048 Disease Relevance 1.62 Pain Relevance 0

Over-expression of PTEN could increase the sensitivity to doxorubicin in human breast cancer MCF-7 cells [22].

Positive_regulation (expression) of Gene_expression (expression) of PTEN in MCF-7 associated with breast cancer

12) Confidence 0.21 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2601048 Disease Relevance 1.62 Pain Relevance 0

activation by rosiglitazone inhibited cell migration through increased expression of PTEN [198].

Positive_regulation (increased) of Gene_expression (expression) of PTEN

13) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.77 Pain Relevance 0.10

Pten deletion leads to neuronal hypertrophy and increased number of TH positive neurons and dendrites in the ventral midbrain

Positive_regulation (leads) of in neurons Gene_expression (deletion) of Pten in dendrites associated with hypertrophy and midbrain

14) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.42 Pain Relevance 0.32

One primary difference observed with the inclusion of microglial cells was increased SY cell gene expression of the tumor suppressor PTEN.

Positive_regulation (increased) of Gene_expression (expression) of PTEN in microglial cells associated with cancer

15) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.56 Pain Relevance 0

-catenin as a result of a PTEN mutation and constitutive inactivation of GSK3?

Positive_regulation (result) of Gene_expression (mutation) of PTEN

16) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650783 Disease Relevance 0 Pain Relevance 0

In this model, gene expression for phosphatase and tensin homolog (PTEN), which functions to modulate cell survival and proliferation primarily through its downstream effects on AKT1, was shown to be significantly increased (Table 6, right).

Positive_regulation (increased) of Gene_expression (expression) of PTEN

17) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.40 Pain Relevance 0

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